Use of near-infrared spectroscopy to monitor regional cerebral oxygen saturation during infrarenal aortic crossclamping in piglets

Akif Undar, Scott A. LeMaire, Zachary C. Schmittling, Joseph S. Coselli, Cüneyt Köksoy, Blake A. Deady, Charles D. Fraser

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: The hemodynamic changes induced by infrarenal aortic crossclamping have been well documented, but the effects of such crossclamping on cerebral perfusion are unknown. To investigate these effects, we used near-infrared spectroscopy (NIRS) to monitor regional cerebral oxygen saturation (rSO2) during infrarenal aortic crossclamping in a piglet model. Methods: The study involved 19 piglets, each weighing 7.8 ± 1 kg. The NIRS sensor was placed on each animal's forehead. General anesthesia was induced, and the infrarenal abdominal aorta was mobilized through a laparotomy. After heparin (1 mg/kg) was administered, crossclamps were applied proximally and distally. A 2 mm segment was resected from the proximal aortic stump, and an aortoaortic anastomosis was performed. Results: Crossclamping lasted for 30. 6 ± 6.7 min. Between the time of baseline measurement and clamp application, the rSO2 did not decrease significantly (65.4% ± 8.9% vs. 62.4% ± 7.8%). However, significant decreases in the rSO 2 occurred between baseline measurement and clamp removal (65.4% ± 8.9% vs. 55.7% ± 8.9%; P < 0.01), between baseline measurement and the end of surgery (65.4% ± 8.9% vs. 57.7% ± 7. 5%; P < 0.01), and between clamp application and removal (62.4% ± 7. 8% vs. 55.7% ± 8.9%; P < 0.01). At these same intervals, no intergroup differences occurred in the temperature, heart rate, or mean arterial pressure. Conclusion: Infrarenal aortic crossclamping significantly decreases the rSO2. NIRS, which has the advantages of being non-invasive and continuous, may be useful for monitoring this variable intraoperatively.

Original languageEnglish (US)
Pages (from-to)849-853
Number of pages5
JournalArtificial organs
Volume27
Issue number9
DOIs
StatePublished - Sep 1 2003

Fingerprint

Near infrared spectroscopy
Near-Infrared Spectroscopy
Clamping devices
Oxygen
Forehead
Abdominal Aorta
Hemodynamics
Weighing
Laparotomy
General Anesthesia
Surgery
Heparin
Arterial Pressure
Animals
Perfusion
Heart Rate
Temperature
Monitoring
Sensors

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Undar, Akif ; LeMaire, Scott A. ; Schmittling, Zachary C. ; Coselli, Joseph S. ; Köksoy, Cüneyt ; Deady, Blake A. ; Fraser, Charles D. / Use of near-infrared spectroscopy to monitor regional cerebral oxygen saturation during infrarenal aortic crossclamping in piglets. In: Artificial organs. 2003 ; Vol. 27, No. 9. pp. 849-853.
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abstract = "Purpose: The hemodynamic changes induced by infrarenal aortic crossclamping have been well documented, but the effects of such crossclamping on cerebral perfusion are unknown. To investigate these effects, we used near-infrared spectroscopy (NIRS) to monitor regional cerebral oxygen saturation (rSO2) during infrarenal aortic crossclamping in a piglet model. Methods: The study involved 19 piglets, each weighing 7.8 ± 1 kg. The NIRS sensor was placed on each animal's forehead. General anesthesia was induced, and the infrarenal abdominal aorta was mobilized through a laparotomy. After heparin (1 mg/kg) was administered, crossclamps were applied proximally and distally. A 2 mm segment was resected from the proximal aortic stump, and an aortoaortic anastomosis was performed. Results: Crossclamping lasted for 30. 6 ± 6.7 min. Between the time of baseline measurement and clamp application, the rSO2 did not decrease significantly (65.4{\%} ± 8.9{\%} vs. 62.4{\%} ± 7.8{\%}). However, significant decreases in the rSO 2 occurred between baseline measurement and clamp removal (65.4{\%} ± 8.9{\%} vs. 55.7{\%} ± 8.9{\%}; P < 0.01), between baseline measurement and the end of surgery (65.4{\%} ± 8.9{\%} vs. 57.7{\%} ± 7. 5{\%}; P < 0.01), and between clamp application and removal (62.4{\%} ± 7. 8{\%} vs. 55.7{\%} ± 8.9{\%}; P < 0.01). At these same intervals, no intergroup differences occurred in the temperature, heart rate, or mean arterial pressure. Conclusion: Infrarenal aortic crossclamping significantly decreases the rSO2. NIRS, which has the advantages of being non-invasive and continuous, may be useful for monitoring this variable intraoperatively.",
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Use of near-infrared spectroscopy to monitor regional cerebral oxygen saturation during infrarenal aortic crossclamping in piglets. / Undar, Akif; LeMaire, Scott A.; Schmittling, Zachary C.; Coselli, Joseph S.; Köksoy, Cüneyt; Deady, Blake A.; Fraser, Charles D.

In: Artificial organs, Vol. 27, No. 9, 01.09.2003, p. 849-853.

Research output: Contribution to journalArticle

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T1 - Use of near-infrared spectroscopy to monitor regional cerebral oxygen saturation during infrarenal aortic crossclamping in piglets

AU - Undar, Akif

AU - LeMaire, Scott A.

AU - Schmittling, Zachary C.

AU - Coselli, Joseph S.

AU - Köksoy, Cüneyt

AU - Deady, Blake A.

AU - Fraser, Charles D.

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N2 - Purpose: The hemodynamic changes induced by infrarenal aortic crossclamping have been well documented, but the effects of such crossclamping on cerebral perfusion are unknown. To investigate these effects, we used near-infrared spectroscopy (NIRS) to monitor regional cerebral oxygen saturation (rSO2) during infrarenal aortic crossclamping in a piglet model. Methods: The study involved 19 piglets, each weighing 7.8 ± 1 kg. The NIRS sensor was placed on each animal's forehead. General anesthesia was induced, and the infrarenal abdominal aorta was mobilized through a laparotomy. After heparin (1 mg/kg) was administered, crossclamps were applied proximally and distally. A 2 mm segment was resected from the proximal aortic stump, and an aortoaortic anastomosis was performed. Results: Crossclamping lasted for 30. 6 ± 6.7 min. Between the time of baseline measurement and clamp application, the rSO2 did not decrease significantly (65.4% ± 8.9% vs. 62.4% ± 7.8%). However, significant decreases in the rSO 2 occurred between baseline measurement and clamp removal (65.4% ± 8.9% vs. 55.7% ± 8.9%; P < 0.01), between baseline measurement and the end of surgery (65.4% ± 8.9% vs. 57.7% ± 7. 5%; P < 0.01), and between clamp application and removal (62.4% ± 7. 8% vs. 55.7% ± 8.9%; P < 0.01). At these same intervals, no intergroup differences occurred in the temperature, heart rate, or mean arterial pressure. Conclusion: Infrarenal aortic crossclamping significantly decreases the rSO2. NIRS, which has the advantages of being non-invasive and continuous, may be useful for monitoring this variable intraoperatively.

AB - Purpose: The hemodynamic changes induced by infrarenal aortic crossclamping have been well documented, but the effects of such crossclamping on cerebral perfusion are unknown. To investigate these effects, we used near-infrared spectroscopy (NIRS) to monitor regional cerebral oxygen saturation (rSO2) during infrarenal aortic crossclamping in a piglet model. Methods: The study involved 19 piglets, each weighing 7.8 ± 1 kg. The NIRS sensor was placed on each animal's forehead. General anesthesia was induced, and the infrarenal abdominal aorta was mobilized through a laparotomy. After heparin (1 mg/kg) was administered, crossclamps were applied proximally and distally. A 2 mm segment was resected from the proximal aortic stump, and an aortoaortic anastomosis was performed. Results: Crossclamping lasted for 30. 6 ± 6.7 min. Between the time of baseline measurement and clamp application, the rSO2 did not decrease significantly (65.4% ± 8.9% vs. 62.4% ± 7.8%). However, significant decreases in the rSO 2 occurred between baseline measurement and clamp removal (65.4% ± 8.9% vs. 55.7% ± 8.9%; P < 0.01), between baseline measurement and the end of surgery (65.4% ± 8.9% vs. 57.7% ± 7. 5%; P < 0.01), and between clamp application and removal (62.4% ± 7. 8% vs. 55.7% ± 8.9%; P < 0.01). At these same intervals, no intergroup differences occurred in the temperature, heart rate, or mean arterial pressure. Conclusion: Infrarenal aortic crossclamping significantly decreases the rSO2. NIRS, which has the advantages of being non-invasive and continuous, may be useful for monitoring this variable intraoperatively.

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