Peptide-nucleic acid (PNA) was found to prevent DNA methylation if the PNA-binding and the methylation sites are adjacent. It can be used in the "Achilles' heel" method to create artificial rare-cutting restriction endonuclease systems. Application of PNA can expand the possibilities of this approach, which conventionally involves DNA-binding proteins or oligonucleotides.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Mar 1 1996|
All Science Journal Classification (ASJC) codes
- Structural Biology