Use of recombinant inbred strains to detect quantitative trait loci associated with behavior

Robert Plomin, Gerald E. McClearn, Grazyna Gora-Maslak, Jenae Marie Neiderhiser

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Recombinant inbred (RI) strains are valuable not only for detecting major gene segregation and linkage but also for identifying associations between behavior and quantitative trait loci (QTL) that account for relatively small amounts of variation in behaviors for which strain distribution patterns are not bimodal. When applied to published data on genetic markers and on behavior for BXD RI strains, the RI QTL association approach suggests the presence of QTLs on chromosomes 6 and 12 for open-field activity and on chromosomes 1, 2, and 17 for high-pressure seizure susceptibility. Because the RI QTL approach does not require that the progenitor inbred strains of a particular RI series differ, researchers could focus on the BXD RI series, for which the greatest number of genetic markers are available. Focusing on BXD would capitalize on the cumulative nature of RI research which permits analyses of QTL sources of genetic correlations across studies.

Original languageEnglish (US)
Pages (from-to)99-116
Number of pages18
JournalBehavior Genetics
Volume21
Issue number2
DOIs
StatePublished - Mar 1 1991

Fingerprint

Quantitative Trait Loci
quantitative trait loci
genetic marker
chromosome
Genetic Markers
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
gene segregation
chromosomes
genetic markers
major genes
seizures
Seizures
gene
genetic correlation
Research Personnel
linkage (genetics)

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Plomin, Robert ; McClearn, Gerald E. ; Gora-Maslak, Grazyna ; Neiderhiser, Jenae Marie. / Use of recombinant inbred strains to detect quantitative trait loci associated with behavior. In: Behavior Genetics. 1991 ; Vol. 21, No. 2. pp. 99-116.
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Use of recombinant inbred strains to detect quantitative trait loci associated with behavior. / Plomin, Robert; McClearn, Gerald E.; Gora-Maslak, Grazyna; Neiderhiser, Jenae Marie.

In: Behavior Genetics, Vol. 21, No. 2, 01.03.1991, p. 99-116.

Research output: Contribution to journalArticle

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