Using smell to triage samples in point-of-care assays

Hemakesh Mohapatra, Scott T. Phillips

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Smell of success: Reagent 1 provides the dual readouts of odor (ethanethiol) and fluorescence (derivative of 7-hydroxycoumarin) and can be used in down-selection assays based on smell and quantitative fluorescence assays of the samples that give a positive result. An important feature of 1 is the matched sensitivity of the two outputs. This reagent is designed for use in resource-limited settings and is demonstrated in assays that detect enzymes.

Original languageEnglish (US)
Pages (from-to)11145-11148
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number44
DOIs
StatePublished - Oct 29 2012

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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