USP21 prevents the generation of T-helper-1-like Treg cells

Yangyang Li, Yue Lu, Shuaiwei Wang, Zhijun Han, Fuxiang Zhu, Yingmeng Ni, Rui Liang, Yan Zhang, Qibin Leng, Gang Wei, Guochao Shi, Ruihong Zhu, Dan Li, Haikun Wang, Song Guo Zheng, Hongxi Xu, Andy Tsun, Bin Li

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

FOXP3 + Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance. Disruption of Foxp3 expression results in the generation of instable Treg cells and acquisition of effector T-cell-like function. Here we report that the E3 deubiquitinase USP21 prevents the depletion of FOXP3 at the protein level and restricts the generation of T-helper-1-like Treg cells. Mice depleted of Usp21 specifically in Treg cells display immune disorders characterized by spontaneous T-cell activation and excessive T-helper type 1 (Th1) skewing of Treg cells into Th1-like Treg cells. USP21 stabilizes FOXP3 protein by mediating its deubiquitination and maintains the expression of Treg signature genes. Our results demonstrate how USP21 prevents FOXP3 protein depletion and controls Treg lineage stability in vivo.

Original languageEnglish (US)
Article number13559
JournalNature communications
Volume7
DOIs
StatePublished - Nov 18 2016

Fingerprint

Regulatory T-Lymphocytes
T-cells
cells
Proteins
proteins
depletion
Genes
Chemical activation
effectors
homeostasis
T-Lymphocytes
Immune Tolerance
Immune System Diseases
genes
maintenance
mice
Transcriptome
acquisition
signatures
activation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Li, Y., Lu, Y., Wang, S., Han, Z., Zhu, F., Ni, Y., ... Li, B. (2016). USP21 prevents the generation of T-helper-1-like Treg cells. Nature communications, 7, [13559]. https://doi.org/10.1038/ncomms13559
Li, Yangyang ; Lu, Yue ; Wang, Shuaiwei ; Han, Zhijun ; Zhu, Fuxiang ; Ni, Yingmeng ; Liang, Rui ; Zhang, Yan ; Leng, Qibin ; Wei, Gang ; Shi, Guochao ; Zhu, Ruihong ; Li, Dan ; Wang, Haikun ; Zheng, Song Guo ; Xu, Hongxi ; Tsun, Andy ; Li, Bin. / USP21 prevents the generation of T-helper-1-like Treg cells. In: Nature communications. 2016 ; Vol. 7.
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Li, Y, Lu, Y, Wang, S, Han, Z, Zhu, F, Ni, Y, Liang, R, Zhang, Y, Leng, Q, Wei, G, Shi, G, Zhu, R, Li, D, Wang, H, Zheng, SG, Xu, H, Tsun, A & Li, B 2016, 'USP21 prevents the generation of T-helper-1-like Treg cells', Nature communications, vol. 7, 13559. https://doi.org/10.1038/ncomms13559

USP21 prevents the generation of T-helper-1-like Treg cells. / Li, Yangyang; Lu, Yue; Wang, Shuaiwei; Han, Zhijun; Zhu, Fuxiang; Ni, Yingmeng; Liang, Rui; Zhang, Yan; Leng, Qibin; Wei, Gang; Shi, Guochao; Zhu, Ruihong; Li, Dan; Wang, Haikun; Zheng, Song Guo; Xu, Hongxi; Tsun, Andy; Li, Bin.

In: Nature communications, Vol. 7, 13559, 18.11.2016.

Research output: Contribution to journalArticle

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AU - Lu, Yue

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AU - Ni, Yingmeng

AU - Liang, Rui

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AU - Leng, Qibin

AU - Wei, Gang

AU - Shi, Guochao

AU - Zhu, Ruihong

AU - Li, Dan

AU - Wang, Haikun

AU - Zheng, Song Guo

AU - Xu, Hongxi

AU - Tsun, Andy

AU - Li, Bin

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