Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection: Implications on Patient Survival

Oliver D. Mrowczynski, Samer Zammar, Alexandre J. Bourcier, Sara T. Langan, Jiangang (Jason) Liao, Charles Specht, Elias Rizk

Research output: Contribution to journalArticle

Abstract

Background: The standard of care for glioblastoma is surgical resection followed by combination temozolomide and radiation. Magnetic resonance imaging (MRI) is used preoperatively for tumor resection planning. In some instances, MRI is also obtained postoperatively to assess for any complications and to determine extent of resection. There is some question whether early routine postoperative imaging of patients after tumor resection is beneficial to long-term outcomes, especially with the increased scrutiny of increasing health care costs. Methods: In this study we retrospectively analyze patients with glioblastoma treated at our institution, comparing the difference in overall survival and treatment regimens between patients who had early postoperative MRI versus patients who did not. Results: We determine that in our cohort of 125 patients, those with early postoperative MRI had no statistically significant overall survival difference compared with patients with no early postoperative MRI (P = 0.996). The median survival for the group with postoperative MRI was 378 days (95% confidence interval [CI], 242–443 days), and the median survival for the group without postoperative MRI was 308 days (95% CI, 203–445 days). Early postoperative MRI also did not significantly alter therapeutic regimens. Conclusions: Although early postoperative MRI may not significantly affect patient overall survival from a statistical standpoint or therapeutic regimens, this type of imaging may be important to hone resident and attending skill. We encourage other institutions to perform similar analyses to determine the overall survival benefit of early postoperative imaging after glioma resection for patients with glioblastoma.

Original languageEnglish (US)
Pages (from-to)e1171-e1174
JournalWorld Neurosurgery
Volume120
DOIs
StatePublished - Dec 1 2018

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Glioblastoma
Magnetic Resonance Imaging
Survival
temozolomide
Confidence Intervals
Standard of Care
Glioma
Health Care Costs
Neoplasms
Therapeutics
Radiation

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

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title = "Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection: Implications on Patient Survival",
abstract = "Background: The standard of care for glioblastoma is surgical resection followed by combination temozolomide and radiation. Magnetic resonance imaging (MRI) is used preoperatively for tumor resection planning. In some instances, MRI is also obtained postoperatively to assess for any complications and to determine extent of resection. There is some question whether early routine postoperative imaging of patients after tumor resection is beneficial to long-term outcomes, especially with the increased scrutiny of increasing health care costs. Methods: In this study we retrospectively analyze patients with glioblastoma treated at our institution, comparing the difference in overall survival and treatment regimens between patients who had early postoperative MRI versus patients who did not. Results: We determine that in our cohort of 125 patients, those with early postoperative MRI had no statistically significant overall survival difference compared with patients with no early postoperative MRI (P = 0.996). The median survival for the group with postoperative MRI was 378 days (95{\%} confidence interval [CI], 242–443 days), and the median survival for the group without postoperative MRI was 308 days (95{\%} CI, 203–445 days). Early postoperative MRI also did not significantly alter therapeutic regimens. Conclusions: Although early postoperative MRI may not significantly affect patient overall survival from a statistical standpoint or therapeutic regimens, this type of imaging may be important to hone resident and attending skill. We encourage other institutions to perform similar analyses to determine the overall survival benefit of early postoperative imaging after glioma resection for patients with glioblastoma.",
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Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection : Implications on Patient Survival. / Mrowczynski, Oliver D.; Zammar, Samer; Bourcier, Alexandre J.; Langan, Sara T.; Liao, Jiangang (Jason); Specht, Charles; Rizk, Elias.

In: World Neurosurgery, Vol. 120, 01.12.2018, p. e1171-e1174.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection

T2 - Implications on Patient Survival

AU - Mrowczynski, Oliver D.

AU - Zammar, Samer

AU - Bourcier, Alexandre J.

AU - Langan, Sara T.

AU - Liao, Jiangang (Jason)

AU - Specht, Charles

AU - Rizk, Elias

PY - 2018/12/1

Y1 - 2018/12/1

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AB - Background: The standard of care for glioblastoma is surgical resection followed by combination temozolomide and radiation. Magnetic resonance imaging (MRI) is used preoperatively for tumor resection planning. In some instances, MRI is also obtained postoperatively to assess for any complications and to determine extent of resection. There is some question whether early routine postoperative imaging of patients after tumor resection is beneficial to long-term outcomes, especially with the increased scrutiny of increasing health care costs. Methods: In this study we retrospectively analyze patients with glioblastoma treated at our institution, comparing the difference in overall survival and treatment regimens between patients who had early postoperative MRI versus patients who did not. Results: We determine that in our cohort of 125 patients, those with early postoperative MRI had no statistically significant overall survival difference compared with patients with no early postoperative MRI (P = 0.996). The median survival for the group with postoperative MRI was 378 days (95% confidence interval [CI], 242–443 days), and the median survival for the group without postoperative MRI was 308 days (95% CI, 203–445 days). Early postoperative MRI also did not significantly alter therapeutic regimens. Conclusions: Although early postoperative MRI may not significantly affect patient overall survival from a statistical standpoint or therapeutic regimens, this type of imaging may be important to hone resident and attending skill. We encourage other institutions to perform similar analyses to determine the overall survival benefit of early postoperative imaging after glioma resection for patients with glioblastoma.

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