Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies.

J. H. Park, N. J. Olsen

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Magnetic resonance imaging (MRI) and P-31 magnetic resonance spectroscopy (P-31 MRS) provide unique, quantitative data that cannot be obtained from routine laboratory tests. MRI is the method of choice for imaging of muscle abnormalities. It is also a very sensitive technique for localizing nonhomogeneous inflammation in inflammatory myopathies such as dermatomyositis, juvenile dermatomyositis, amyopathic dermatomyositis, polymyositis, and inclusion body myositis. During treatment of inflammatory myopathies, the extent and severity of inflammation may decrease at varying rates, but weakness and fatigue remain serious clinical problems. The metabolic abnormalities detected with P-31 MRS are more persistent and can be used for objective patient evaluation after the disappearance of inflammation and normalization of serum levels of muscle enzymes. With P-31 MRS, biochemical defects are quantitated, including low levels of ATP and phosphocreatine (PCr) and elevated concentrations of ADP and inorganic phosphate (Pi), which may all be related to weakness and fatigue. Thus, MRI and P-31 MRS are useful in assessing the status of patients with inflammatory myopathies during treatment with prednisone and immunosuppressive drugs.

Original languageEnglish (US)
Pages (from-to)334-345
Number of pages12
JournalCurrent rheumatology reports
Volume3
Issue number4
DOIs
StatePublished - Aug 2001

Fingerprint

Myositis
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Inflammation
Fatigue
Inclusion Body Myositis
Polymyositis
Muscles
Dermatomyositis
Phosphocreatine
Immunosuppressive Agents
Prednisone
Adenosine Diphosphate
Adenosine Triphosphate
Phosphates
Enzymes
Therapeutics
Serum
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

@article{31ca8ec1cbae45c8a2e4f23bb1ddd7e5,
title = "Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies.",
abstract = "Magnetic resonance imaging (MRI) and P-31 magnetic resonance spectroscopy (P-31 MRS) provide unique, quantitative data that cannot be obtained from routine laboratory tests. MRI is the method of choice for imaging of muscle abnormalities. It is also a very sensitive technique for localizing nonhomogeneous inflammation in inflammatory myopathies such as dermatomyositis, juvenile dermatomyositis, amyopathic dermatomyositis, polymyositis, and inclusion body myositis. During treatment of inflammatory myopathies, the extent and severity of inflammation may decrease at varying rates, but weakness and fatigue remain serious clinical problems. The metabolic abnormalities detected with P-31 MRS are more persistent and can be used for objective patient evaluation after the disappearance of inflammation and normalization of serum levels of muscle enzymes. With P-31 MRS, biochemical defects are quantitated, including low levels of ATP and phosphocreatine (PCr) and elevated concentrations of ADP and inorganic phosphate (Pi), which may all be related to weakness and fatigue. Thus, MRI and P-31 MRS are useful in assessing the status of patients with inflammatory myopathies during treatment with prednisone and immunosuppressive drugs.",
author = "Park, {J. H.} and Olsen, {N. J.}",
year = "2001",
month = "8",
doi = "10.1007/s11926-001-0038-x",
language = "English (US)",
volume = "3",
pages = "334--345",
journal = "Current Rheumatology Reports",
issn = "1523-3774",
publisher = "Current Science, Inc.",
number = "4",

}

Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies. / Park, J. H.; Olsen, N. J.

In: Current rheumatology reports, Vol. 3, No. 4, 08.2001, p. 334-345.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies.

AU - Park, J. H.

AU - Olsen, N. J.

PY - 2001/8

Y1 - 2001/8

N2 - Magnetic resonance imaging (MRI) and P-31 magnetic resonance spectroscopy (P-31 MRS) provide unique, quantitative data that cannot be obtained from routine laboratory tests. MRI is the method of choice for imaging of muscle abnormalities. It is also a very sensitive technique for localizing nonhomogeneous inflammation in inflammatory myopathies such as dermatomyositis, juvenile dermatomyositis, amyopathic dermatomyositis, polymyositis, and inclusion body myositis. During treatment of inflammatory myopathies, the extent and severity of inflammation may decrease at varying rates, but weakness and fatigue remain serious clinical problems. The metabolic abnormalities detected with P-31 MRS are more persistent and can be used for objective patient evaluation after the disappearance of inflammation and normalization of serum levels of muscle enzymes. With P-31 MRS, biochemical defects are quantitated, including low levels of ATP and phosphocreatine (PCr) and elevated concentrations of ADP and inorganic phosphate (Pi), which may all be related to weakness and fatigue. Thus, MRI and P-31 MRS are useful in assessing the status of patients with inflammatory myopathies during treatment with prednisone and immunosuppressive drugs.

AB - Magnetic resonance imaging (MRI) and P-31 magnetic resonance spectroscopy (P-31 MRS) provide unique, quantitative data that cannot be obtained from routine laboratory tests. MRI is the method of choice for imaging of muscle abnormalities. It is also a very sensitive technique for localizing nonhomogeneous inflammation in inflammatory myopathies such as dermatomyositis, juvenile dermatomyositis, amyopathic dermatomyositis, polymyositis, and inclusion body myositis. During treatment of inflammatory myopathies, the extent and severity of inflammation may decrease at varying rates, but weakness and fatigue remain serious clinical problems. The metabolic abnormalities detected with P-31 MRS are more persistent and can be used for objective patient evaluation after the disappearance of inflammation and normalization of serum levels of muscle enzymes. With P-31 MRS, biochemical defects are quantitated, including low levels of ATP and phosphocreatine (PCr) and elevated concentrations of ADP and inorganic phosphate (Pi), which may all be related to weakness and fatigue. Thus, MRI and P-31 MRS are useful in assessing the status of patients with inflammatory myopathies during treatment with prednisone and immunosuppressive drugs.

UR - http://www.scopus.com/inward/record.url?scp=0035432344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035432344&partnerID=8YFLogxK

U2 - 10.1007/s11926-001-0038-x

DO - 10.1007/s11926-001-0038-x

M3 - Review article

C2 - 11470053

AN - SCOPUS:0035432344

VL - 3

SP - 334

EP - 345

JO - Current Rheumatology Reports

JF - Current Rheumatology Reports

SN - 1523-3774

IS - 4

ER -