Utility of the VDRL test in HIV-seropositive patients

Joseph Drabick, Edmund C. Tramont

Research output: Contribution to journalLetter

11 Citations (Scopus)

Abstract

To the Editor: The Venereal Disease Research Laboratory (VDRL) and other nontreponemal tests for syphilis measure the levels of antibody directed against a cardiolipin—lecithin antigen. False positive reactions can occur in patients with immunoglobulin abnormalities. Patients infected with the human immunodeficiency virus (HIV) often have polyclonal gammopathy, and a majority have anticardiolipin antibodies.1 False positive nontreponemal tests in patients with HIV make it difficult to evaluate the response to therapy in patients who have syphilis, as exemplified by the following case report. A 61-year-old man with a history of heterosexual promiscuity and syphilis treated in the 1950s presented with hairy.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume322
Issue number4
DOIs
StatePublished - Jan 25 1990

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Sexually Transmitted Diseases
Syphilis
HIV
Research
False Positive Reactions
Heterosexuality
Immunoglobulins
Antigens
Antibodies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Utility of the VDRL test in HIV-seropositive patients",
abstract = "To the Editor: The Venereal Disease Research Laboratory (VDRL) and other nontreponemal tests for syphilis measure the levels of antibody directed against a cardiolipin—lecithin antigen. False positive reactions can occur in patients with immunoglobulin abnormalities. Patients infected with the human immunodeficiency virus (HIV) often have polyclonal gammopathy, and a majority have anticardiolipin antibodies.1 False positive nontreponemal tests in patients with HIV make it difficult to evaluate the response to therapy in patients who have syphilis, as exemplified by the following case report. A 61-year-old man with a history of heterosexual promiscuity and syphilis treated in the 1950s presented with hairy.",
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Utility of the VDRL test in HIV-seropositive patients. / Drabick, Joseph; Tramont, Edmund C.

In: New England Journal of Medicine, Vol. 322, No. 4, 25.01.1990.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Utility of the VDRL test in HIV-seropositive patients

AU - Drabick, Joseph

AU - Tramont, Edmund C.

PY - 1990/1/25

Y1 - 1990/1/25

N2 - To the Editor: The Venereal Disease Research Laboratory (VDRL) and other nontreponemal tests for syphilis measure the levels of antibody directed against a cardiolipin—lecithin antigen. False positive reactions can occur in patients with immunoglobulin abnormalities. Patients infected with the human immunodeficiency virus (HIV) often have polyclonal gammopathy, and a majority have anticardiolipin antibodies.1 False positive nontreponemal tests in patients with HIV make it difficult to evaluate the response to therapy in patients who have syphilis, as exemplified by the following case report. A 61-year-old man with a history of heterosexual promiscuity and syphilis treated in the 1950s presented with hairy.

AB - To the Editor: The Venereal Disease Research Laboratory (VDRL) and other nontreponemal tests for syphilis measure the levels of antibody directed against a cardiolipin—lecithin antigen. False positive reactions can occur in patients with immunoglobulin abnormalities. Patients infected with the human immunodeficiency virus (HIV) often have polyclonal gammopathy, and a majority have anticardiolipin antibodies.1 False positive nontreponemal tests in patients with HIV make it difficult to evaluate the response to therapy in patients who have syphilis, as exemplified by the following case report. A 61-year-old man with a history of heterosexual promiscuity and syphilis treated in the 1950s presented with hairy.

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