Utilizing regulatory T cells against rheumatoid arthritis

Mohammad Haque, Kristin Fino, Fengyang Lei, Xiaofang Xiong, Jianxun Song

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Regulatory T (Treg) cells are essential for normal immune surveillance systems, and their dysfunction leads to development of diseases, such as autoimmune disorders. CD4+ CD25+ Treg cells are well-known suppressive cells which express the transcription factor Foxp3, are indispensable for the maintenance of immune self-tolerance and homeostasis by suppressing aberrant or excessive immune response. Other Foxp3- Treg cells include Tr1, Th3, CD8+CD28-/-, and Qa1-restricted T cells; however, the contribution of these Treg cells to self-tolerance, immune homeostasis as well as preventing autoimmunity is not well defined. Here we discuss the phenotypes and function of Foxp3+ Treg cells and the potential use of such Treg cells against rheumatoid arthritis. Of note, even though most expanded populations of Foxp3+ Treg cells exhibit suppressive activity, tissue-associated or antigen-specific Treg cells appear superior in suppressing local autoimmune disorders such as rheumatoid arthritis. In addition, utilizing tissueassociated Foxp3+ Treg cells from stem cells may stable Foxp3 expression and avoid induction of a potentially detrimental systemic immunosuppression.

Original languageEnglish (US)
Article number209
JournalFrontiers in Oncology
Volume4 JUL
DOIs
StatePublished - Jan 1 2014

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Regulatory T-Lymphocytes
Rheumatoid Arthritis
Self Tolerance
Homeostasis
Immune Tolerance
Autoimmunity
Immunosuppression
Immune System
Transcription Factors
Stem Cells
Maintenance
T-Lymphocytes
Phenotype
Antigens

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Haque, M., Fino, K., Lei, F., Xiong, X., & Song, J. (2014). Utilizing regulatory T cells against rheumatoid arthritis. Frontiers in Oncology, 4 JUL, [209]. https://doi.org/10.3389/fonc.2014.00209
Haque, Mohammad ; Fino, Kristin ; Lei, Fengyang ; Xiong, Xiaofang ; Song, Jianxun. / Utilizing regulatory T cells against rheumatoid arthritis. In: Frontiers in Oncology. 2014 ; Vol. 4 JUL.
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Utilizing regulatory T cells against rheumatoid arthritis. / Haque, Mohammad; Fino, Kristin; Lei, Fengyang; Xiong, Xiaofang; Song, Jianxun.

In: Frontiers in Oncology, Vol. 4 JUL, 209, 01.01.2014.

Research output: Contribution to journalReview article

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AU - Haque, Mohammad

AU - Fino, Kristin

AU - Lei, Fengyang

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