Vagal neurocircuitry and its influence on gastric motility

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

A large body of research has been dedicated to the effects of gastrointestinal peptides on vagal afferent fibres, yet multiple lines of evidence indicate that gastrointestinal peptides also modulate brainstem vagal neurocircuitry, and that this modulation has a fundamental role in the physiology and pathophysiology of the upper gastrointestinal tract. In fact, brainstem vagovagal neurocircuits comprise highly plastic neurons and synapses connecting afferent vagal fibres, second order neurons of the nucleus tractus solitarius (NTS), and efferent fibres originating in the dorsal motor nucleus of the vagus (DMV). Neuronal communication between the NTS and DMV is regulated by the presence of a variety of inputs, both from within the brainstem itself as well as from higher centres, which utilize an array of neurotransmitters and neuromodulators. Because of the circumventricular nature of these brainstem areas, circulating hormones can also modulate the vagal output to the upper gastrointestinal tract. This Review summarizes the organization and function of vagovagal reflex control of the upper gastrointestinal tract, presents data on the plasticity within these neurocircuits after stress, and discusses the gastrointestinal dysfunctions observed in Parkinson disease as examples of physiological adjustment and maladaptation of these reflexes.

Original languageEnglish (US)
Pages (from-to)389-401
Number of pages13
JournalNature Reviews Gastroenterology and Hepatology
Volume13
Issue number7
DOIs
StatePublished - Jul 1 2016

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Brain Stem
Upper Gastrointestinal Tract
Stomach
Solitary Nucleus
Neurotransmitter Agents
Reflex
Social Adjustment
Neurons
Peptides
Synapses
Plastics
Parkinson Disease
Communication
Hormones
Research

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

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Vagal neurocircuitry and its influence on gastric motility. / Travagli, Renato Alberto; Anselmi, Laura.

In: Nature Reviews Gastroenterology and Hepatology, Vol. 13, No. 7, 01.07.2016, p. 389-401.

Research output: Contribution to journalReview article

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