Valproate attenuates dextroamphetamine-induced subjective changes more than lithium

Morgan C. Willson, Emily C. Bell, Sanjay Dave, Sheila Asghar, Brent M. McGrath, Peter H. Silverstone

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Dextroamphetamine administration in healthy controls produces a range of subjective and physiological effects, which have been likened to those occurring during mania. However, it is uncertain if these can be attenuated by lithium since conflicting results have been reported. To date there have been no previous studies examining the effects of valproate on dextroamphetamine-induced mood and physiological changes. The current study was a double-blind, placebo-controlled, study in which volunteers received either 1000 mg sodium valproate (n = 12), 900 mg lithium (n = 9), or placebo (n = 12) pre-treatment for 14 days. Subjective and physiological measures were then obtained prior to administration of a 25 mg dose of dextroamphetamine, and at two time points after administration. Differences in the response to dextroamphetamine were assessed between the three treatment groups. The results of this study show that pre-treatment with lithium only significantly attenuated dextroamphetamine- induced change in happiness, while valproate pre-treatment significantly attenuated the effects of dextroamphetamine on happiness, energy, alertness and on the diastolic blood pressure. These results suggest that lithium and valproate do not have the same mechanism of action on dextroamphetamine-induced changes, and this finding may relate to differences in their mechanism of action in mood disorders.

Original languageEnglish (US)
Pages (from-to)633-639
Number of pages7
JournalEuropean Neuropsychopharmacology
Volume15
Issue number6
DOIs
StatePublished - Dec 1 2005

Fingerprint

Dextroamphetamine
Valproic Acid
Lithium
Happiness
Placebos
Blood Pressure
Therapeutics
Mood Disorders
Bipolar Disorder
Volunteers

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Cite this

Willson, M. C., Bell, E. C., Dave, S., Asghar, S., McGrath, B. M., & Silverstone, P. H. (2005). Valproate attenuates dextroamphetamine-induced subjective changes more than lithium. European Neuropsychopharmacology, 15(6), 633-639. https://doi.org/10.1016/j.euroneuro.2005.04.015
Willson, Morgan C. ; Bell, Emily C. ; Dave, Sanjay ; Asghar, Sheila ; McGrath, Brent M. ; Silverstone, Peter H. / Valproate attenuates dextroamphetamine-induced subjective changes more than lithium. In: European Neuropsychopharmacology. 2005 ; Vol. 15, No. 6. pp. 633-639.
@article{eb220348d741444f82a64aa591bda0c1,
title = "Valproate attenuates dextroamphetamine-induced subjective changes more than lithium",
abstract = "Dextroamphetamine administration in healthy controls produces a range of subjective and physiological effects, which have been likened to those occurring during mania. However, it is uncertain if these can be attenuated by lithium since conflicting results have been reported. To date there have been no previous studies examining the effects of valproate on dextroamphetamine-induced mood and physiological changes. The current study was a double-blind, placebo-controlled, study in which volunteers received either 1000 mg sodium valproate (n = 12), 900 mg lithium (n = 9), or placebo (n = 12) pre-treatment for 14 days. Subjective and physiological measures were then obtained prior to administration of a 25 mg dose of dextroamphetamine, and at two time points after administration. Differences in the response to dextroamphetamine were assessed between the three treatment groups. The results of this study show that pre-treatment with lithium only significantly attenuated dextroamphetamine- induced change in happiness, while valproate pre-treatment significantly attenuated the effects of dextroamphetamine on happiness, energy, alertness and on the diastolic blood pressure. These results suggest that lithium and valproate do not have the same mechanism of action on dextroamphetamine-induced changes, and this finding may relate to differences in their mechanism of action in mood disorders.",
author = "Willson, {Morgan C.} and Bell, {Emily C.} and Sanjay Dave and Sheila Asghar and McGrath, {Brent M.} and Silverstone, {Peter H.}",
year = "2005",
month = "12",
day = "1",
doi = "10.1016/j.euroneuro.2005.04.015",
language = "English (US)",
volume = "15",
pages = "633--639",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier",
number = "6",

}

Willson, MC, Bell, EC, Dave, S, Asghar, S, McGrath, BM & Silverstone, PH 2005, 'Valproate attenuates dextroamphetamine-induced subjective changes more than lithium', European Neuropsychopharmacology, vol. 15, no. 6, pp. 633-639. https://doi.org/10.1016/j.euroneuro.2005.04.015

Valproate attenuates dextroamphetamine-induced subjective changes more than lithium. / Willson, Morgan C.; Bell, Emily C.; Dave, Sanjay; Asghar, Sheila; McGrath, Brent M.; Silverstone, Peter H.

In: European Neuropsychopharmacology, Vol. 15, No. 6, 01.12.2005, p. 633-639.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Valproate attenuates dextroamphetamine-induced subjective changes more than lithium

AU - Willson, Morgan C.

AU - Bell, Emily C.

AU - Dave, Sanjay

AU - Asghar, Sheila

AU - McGrath, Brent M.

AU - Silverstone, Peter H.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Dextroamphetamine administration in healthy controls produces a range of subjective and physiological effects, which have been likened to those occurring during mania. However, it is uncertain if these can be attenuated by lithium since conflicting results have been reported. To date there have been no previous studies examining the effects of valproate on dextroamphetamine-induced mood and physiological changes. The current study was a double-blind, placebo-controlled, study in which volunteers received either 1000 mg sodium valproate (n = 12), 900 mg lithium (n = 9), or placebo (n = 12) pre-treatment for 14 days. Subjective and physiological measures were then obtained prior to administration of a 25 mg dose of dextroamphetamine, and at two time points after administration. Differences in the response to dextroamphetamine were assessed between the three treatment groups. The results of this study show that pre-treatment with lithium only significantly attenuated dextroamphetamine- induced change in happiness, while valproate pre-treatment significantly attenuated the effects of dextroamphetamine on happiness, energy, alertness and on the diastolic blood pressure. These results suggest that lithium and valproate do not have the same mechanism of action on dextroamphetamine-induced changes, and this finding may relate to differences in their mechanism of action in mood disorders.

AB - Dextroamphetamine administration in healthy controls produces a range of subjective and physiological effects, which have been likened to those occurring during mania. However, it is uncertain if these can be attenuated by lithium since conflicting results have been reported. To date there have been no previous studies examining the effects of valproate on dextroamphetamine-induced mood and physiological changes. The current study was a double-blind, placebo-controlled, study in which volunteers received either 1000 mg sodium valproate (n = 12), 900 mg lithium (n = 9), or placebo (n = 12) pre-treatment for 14 days. Subjective and physiological measures were then obtained prior to administration of a 25 mg dose of dextroamphetamine, and at two time points after administration. Differences in the response to dextroamphetamine were assessed between the three treatment groups. The results of this study show that pre-treatment with lithium only significantly attenuated dextroamphetamine- induced change in happiness, while valproate pre-treatment significantly attenuated the effects of dextroamphetamine on happiness, energy, alertness and on the diastolic blood pressure. These results suggest that lithium and valproate do not have the same mechanism of action on dextroamphetamine-induced changes, and this finding may relate to differences in their mechanism of action in mood disorders.

UR - http://www.scopus.com/inward/record.url?scp=27744521375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744521375&partnerID=8YFLogxK

U2 - 10.1016/j.euroneuro.2005.04.015

DO - 10.1016/j.euroneuro.2005.04.015

M3 - Article

C2 - 15949922

AN - SCOPUS:27744521375

VL - 15

SP - 633

EP - 639

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 6

ER -