Valvular and Mural Endocardiosis in Aging Zebrafish (Danio rerio)

Timothy Cooper, J. M. Spitsbergen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Endocardiosis or myxomatous degeneration of the cardiac valves is a well-described age-related change in humans and dogs. Lesions consist of polypoid nodular proliferations of loose extracellular matrix and valvular interstitial cells, most commonly affecting the mitral valve. This entity has not been previously described in fish. Herein we report the appearance, location, and occurrence of valvular and mural endocardiosis in a retrospective survey of aging laboratory zebrafish. Endocardiosis was present in 59 of 777 fish (7.59%), most commonly affecting the sinoatrial (34 fish; 57.6%) and atrioventricular (33 fish; 55.9%) valves. Lesions were more common in fish raised in recirculating water systems and fed commercial diets (52/230 fish; 22.6%) versus flow-through systems with fish fed semi-purified diets (4/234; 1.71%). Lesions were overrepresented in fish heterozygous for a mutant smoothened allele (34/61 fish, 55.7% vs 17/168, 10.1% wild type). There was no association between endocardiosis and intestinal carcinoids. Valvular endocardiosis is a significant age- and husbandry-related background finding in zebrafish and should be considered in the design and interpretation of research studies.

Original languageEnglish (US)
Pages (from-to)504-509
Number of pages6
JournalVeterinary Pathology
Volume53
Issue number2
DOIs
StatePublished - Mar 1 2016

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Zebrafish
Danio rerio
Fishes
fish
lesions (animal)
Diet
Heart Valves
Carcinoid Tumor
extracellular matrix
diet
fish feeds
Mitral Valve
Extracellular Matrix
Research Design
alleles
Alleles
Dogs
mutants
dogs
Water

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Cooper, Timothy ; Spitsbergen, J. M. / Valvular and Mural Endocardiosis in Aging Zebrafish (Danio rerio). In: Veterinary Pathology. 2016 ; Vol. 53, No. 2. pp. 504-509.
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Valvular and Mural Endocardiosis in Aging Zebrafish (Danio rerio). / Cooper, Timothy; Spitsbergen, J. M.

In: Veterinary Pathology, Vol. 53, No. 2, 01.03.2016, p. 504-509.

Research output: Contribution to journalArticle

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