Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression: Within-treatment analysis in the RAINBOW trial

Nan Lv; Lan Xiao; Marzieh Majd; Philip W. Lavori; Joshua M. Smyth; Lisa G. Rosas; Elizabeth M. Venditti; Mark B. Snowden; Megan A. Lewis; Elizabeth Ward; Lenard Lesser; Leanne M. Williams; Kristen M.J. Azar; Jun Ma

doi:10.1371/journal.pone.0231743

Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression: Within-treatment analysis in the RAINBOW trial

Nan Lv, Lan Xiao, Marzieh Majd, Philip W. Lavori, Joshua M. Smyth, Lisa G. Rosas, Elizabeth M. Venditti, Mark B. Snowden, Megan A. Lewis, Elizabeth Ward, Lenard Lesser, Leanne M. Williams, Kristen M.J. Azar, Jun Ma

Research output: Contribution to journal › Article

Abstract

Introduction The RAINBOW randomized clinical trial validated the efficacy of an integrated collaborative care intervention for obesity and depression in primary care, although the effect was modest. To inform intervention optimization, this study investigated within-treatment variability in participant engagement and progress. Methods Data were collected in 2014–2017 and analyzed post hoc in 2018. Cluster analysis evaluated patterns of change in weekly self-monitored weight from week 6 up to week 52 and depression scores on the Patient Health Questionnaire-9 (PHQ-9) from up to 15 individual sessions during the 12-month intervention. Chi-square tests and ANOVA compared weight loss and depression outcomes objectively measured by blinded assessors to validate differences among categories of treatment engagement and progress defined based on cluster analysis results.

Original language	English (US)
Article number	e0231743
Journal	PloS one
Volume	15
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0231743
State	Published - Apr 2020

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All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
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Lv, N., Xiao, L., Majd, M., Lavori, P. W., Smyth, J. M., Rosas, L. G., Venditti, E. M., Snowden, M. B., Lewis, M. A., Ward, E., Lesser, L., Williams, L. M., Azar, K. M. J., & Ma, J. (2020). Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression: Within-treatment analysis in the RAINBOW trial. PloS one, 15(4), [e0231743]. https://doi.org/10.1371/journal.pone.0231743

Lv, Nan ; Xiao, Lan ; Majd, Marzieh ; Lavori, Philip W. ; Smyth, Joshua M. ; Rosas, Lisa G. ; Venditti, Elizabeth M. ; Snowden, Mark B. ; Lewis, Megan A. ; Ward, Elizabeth ; Lesser, Lenard ; Williams, Leanne M. ; Azar, Kristen M.J. ; Ma, Jun. / Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression : Within-treatment analysis in the RAINBOW trial. In: PloS one. 2020 ; Vol. 15, No. 4.

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abstract = "Introduction The RAINBOW randomized clinical trial validated the efficacy of an integrated collaborative care intervention for obesity and depression in primary care, although the effect was modest. To inform intervention optimization, this study investigated within-treatment variability in participant engagement and progress. Methods Data were collected in 2014–2017 and analyzed post hoc in 2018. Cluster analysis evaluated patterns of change in weekly self-monitored weight from week 6 up to week 52 and depression scores on the Patient Health Questionnaire-9 (PHQ-9) from up to 15 individual sessions during the 12-month intervention. Chi-square tests and ANOVA compared weight loss and depression outcomes objectively measured by blinded assessors to validate differences among categories of treatment engagement and progress defined based on cluster analysis results.",

author = "Nan Lv and Lan Xiao and Marzieh Majd and Lavori, {Philip W.} and Smyth, {Joshua M.} and Rosas, {Lisa G.} and Venditti, {Elizabeth M.} and Snowden, {Mark B.} and Lewis, {Megan A.} and Elizabeth Ward and Lenard Lesser and Williams, {Leanne M.} and Azar, {Kristen M.J.} and Jun Ma",

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Lv, N, Xiao, L, Majd, M, Lavori, PW, Smyth, JM, Rosas, LG, Venditti, EM, Snowden, MB, Lewis, MA, Ward, E, Lesser, L, Williams, LM, Azar, KMJ & Ma, J 2020, 'Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression: Within-treatment analysis in the RAINBOW trial', PloS one, vol. 15, no. 4, e0231743. https://doi.org/10.1371/journal.pone.0231743

Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression : Within-treatment analysis in the RAINBOW trial. / Lv, Nan; Xiao, Lan; Majd, Marzieh; Lavori, Philip W.; Smyth, Joshua M.; Rosas, Lisa G.; Venditti, Elizabeth M.; Snowden, Mark B.; Lewis, Megan A.; Ward, Elizabeth; Lesser, Lenard; Williams, Leanne M.; Azar, Kristen M.J.; Ma, Jun.

In: PloS one, Vol. 15, No. 4, e0231743, 04.2020.

Research output: Contribution to journal › Article

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T1 - Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression

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AU - Lv, Nan

AU - Xiao, Lan

AU - Majd, Marzieh

AU - Lavori, Philip W.

AU - Smyth, Joshua M.

AU - Rosas, Lisa G.

AU - Venditti, Elizabeth M.

AU - Snowden, Mark B.

AU - Lewis, Megan A.

AU - Ward, Elizabeth

AU - Lesser, Lenard

AU - Williams, Leanne M.

AU - Azar, Kristen M.J.

AU - Ma, Jun

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