@article{8f2b952c191749248b1f5b6bc8b948e6,
title = "Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression: Within-treatment analysis in the RAINBOW trial",
abstract = "Introduction The RAINBOW randomized clinical trial validated the efficacy of an integrated collaborative care intervention for obesity and depression in primary care, although the effect was modest. To inform intervention optimization, this study investigated within-treatment variability in participant engagement and progress. Methods Data were collected in 2014–2017 and analyzed post hoc in 2018. Cluster analysis evaluated patterns of change in weekly self-monitored weight from week 6 up to week 52 and depression scores on the Patient Health Questionnaire-9 (PHQ-9) from up to 15 individual sessions during the 12-month intervention. Chi-square tests and ANOVA compared weight loss and depression outcomes objectively measured by blinded assessors to validate differences among categories of treatment engagement and progress defined based on cluster analysis results.",
author = "Nan Lv and Lan Xiao and Marzieh Majd and Lavori, {Philip W.} and Smyth, {Joshua M.} and Rosas, {Lisa G.} and Venditti, {Elizabeth M.} and Snowden, {Mark B.} and Lewis, {Megan A.} and Elizabeth Ward and Lenard Lesser and Williams, {Leanne M.} and Azar, {Kristen M.J.} and Jun Ma",
note = "Funding Information: ?Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health (URL: https://www.nhlbi.nih.gov/) under Award Number R01HL119453 (Recipient: JM). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. There were no other funding sources.? The following research team members contributed instrumentally to the delivery of the I-CARE intervention: Andrea Blonstein, MBA, RD (Sutter Health) and Hoang Nguyen (Blue Shield of California). Dr. Ma had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Concept and design: Ma, Lavori. Acquisition, analysis, or interpretation of data: All authors. Drafting of the manuscript: Lv, Xiao, Majd. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: Lv, Xiao, Lavori, Ma. Obtaining funding: Ma, Lewis, Lavori. Administrative, technical, or material support: Lv, Rosas, Azar, Snowden, Venditti, Lewis, Ward, Lesser, Ma. Supervision: Ma, Rosas. Publisher Copyright: {\textcopyright} 2020 Lv et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2020",
month = apr,
doi = "10.1371/journal.pone.0231743",
language = "English (US)",
volume = "15",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",
}