Variability of treatment selection among surgeons for patients with cT1 urothelial carcinoma

Guido Dalbagni, Matthew G. Kaag, Angel Cronin, Kinjal Vora, Bernard Bochner, S. MacHele Donat, Harry W. Herr

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: To report the heterogeneity in the treatment of patients with cT1 urothelial carcinoma by different surgeons, and to report outcomes in patients with and without bacillus Calmette-Guérin (BCG) treatment. Patients and Methods We retrospectively reviewed 396 patients who had undergone a re-staging transurethral resection (TUR) for cT1 bladder cancer. We assessed both differences in the treatment by surgeon, and the association of early treatment with BCG with recurrence, progression and bladder cancer-specific death. Results: Muscle was captured in the re-staging TUR specimen in a median of 76% of patients (range 50-94 when stratified by surgeon). On multivariable analysis there was significant heterogeneity among surgeons in the use of early cystectomy (P < 0.001), deferred cystectomy (P < 0.001), and BCG (P= 0.014). However, there was no significant heterogeneity between surgeons in clinical outcome for recurrence (P= 0.9) and overall survival (P= 0.3). Among 288 patients placed on surveillance, the 5-year probability (95% confidence interval) of freedom from recurrence was 45 (36-54)% for those receiving and 54 (44-62)% for those not receiving early BCG. On multivariable analysis, early BCG was not significantly associated with recurrence (P= 0.14). The cumulative incidence of progression was ≈10% for both groups, and the cumulative incidence of bladder cancer-specific death was ≈7% for both groups. The cumulative incidence of deferred cystectomy before progression was 14% for those receiving and 15% for those not receiving early BCG. Conclusion S There is a significant variability among surgeons in the management of patients with T1 disease. The similar outcome for the BCG-treated and-untreated patients in our study is most likely confounded by patient selection.

Original languageEnglish (US)
Pages (from-to)1502-1507
Number of pages6
JournalBJU International
Volume106
Issue number10
DOIs
StatePublished - Nov 1 2010

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Bacillus
Carcinoma
Cystectomy
Urinary Bladder Neoplasms
Recurrence
Therapeutics
Incidence
Surgeons
Patient Selection
Confidence Intervals
Muscles
Survival

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Dalbagni, Guido ; Kaag, Matthew G. ; Cronin, Angel ; Vora, Kinjal ; Bochner, Bernard ; Donat, S. MacHele ; Herr, Harry W. / Variability of treatment selection among surgeons for patients with cT1 urothelial carcinoma. In: BJU International. 2010 ; Vol. 106, No. 10. pp. 1502-1507.
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abstract = "Objectives: To report the heterogeneity in the treatment of patients with cT1 urothelial carcinoma by different surgeons, and to report outcomes in patients with and without bacillus Calmette-Gu{\'e}rin (BCG) treatment. Patients and Methods We retrospectively reviewed 396 patients who had undergone a re-staging transurethral resection (TUR) for cT1 bladder cancer. We assessed both differences in the treatment by surgeon, and the association of early treatment with BCG with recurrence, progression and bladder cancer-specific death. Results: Muscle was captured in the re-staging TUR specimen in a median of 76{\%} of patients (range 50-94 when stratified by surgeon). On multivariable analysis there was significant heterogeneity among surgeons in the use of early cystectomy (P < 0.001), deferred cystectomy (P < 0.001), and BCG (P= 0.014). However, there was no significant heterogeneity between surgeons in clinical outcome for recurrence (P= 0.9) and overall survival (P= 0.3). Among 288 patients placed on surveillance, the 5-year probability (95{\%} confidence interval) of freedom from recurrence was 45 (36-54){\%} for those receiving and 54 (44-62){\%} for those not receiving early BCG. On multivariable analysis, early BCG was not significantly associated with recurrence (P= 0.14). The cumulative incidence of progression was ≈10{\%} for both groups, and the cumulative incidence of bladder cancer-specific death was ≈7{\%} for both groups. The cumulative incidence of deferred cystectomy before progression was 14{\%} for those receiving and 15{\%} for those not receiving early BCG. Conclusion S There is a significant variability among surgeons in the management of patients with T1 disease. The similar outcome for the BCG-treated and-untreated patients in our study is most likely confounded by patient selection.",
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Variability of treatment selection among surgeons for patients with cT1 urothelial carcinoma. / Dalbagni, Guido; Kaag, Matthew G.; Cronin, Angel; Vora, Kinjal; Bochner, Bernard; Donat, S. MacHele; Herr, Harry W.

In: BJU International, Vol. 106, No. 10, 01.11.2010, p. 1502-1507.

Research output: Contribution to journalArticle

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AU - Dalbagni, Guido

AU - Kaag, Matthew G.

AU - Cronin, Angel

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AU - Bochner, Bernard

AU - Donat, S. MacHele

AU - Herr, Harry W.

PY - 2010/11/1

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N2 - Objectives: To report the heterogeneity in the treatment of patients with cT1 urothelial carcinoma by different surgeons, and to report outcomes in patients with and without bacillus Calmette-Guérin (BCG) treatment. Patients and Methods We retrospectively reviewed 396 patients who had undergone a re-staging transurethral resection (TUR) for cT1 bladder cancer. We assessed both differences in the treatment by surgeon, and the association of early treatment with BCG with recurrence, progression and bladder cancer-specific death. Results: Muscle was captured in the re-staging TUR specimen in a median of 76% of patients (range 50-94 when stratified by surgeon). On multivariable analysis there was significant heterogeneity among surgeons in the use of early cystectomy (P < 0.001), deferred cystectomy (P < 0.001), and BCG (P= 0.014). However, there was no significant heterogeneity between surgeons in clinical outcome for recurrence (P= 0.9) and overall survival (P= 0.3). Among 288 patients placed on surveillance, the 5-year probability (95% confidence interval) of freedom from recurrence was 45 (36-54)% for those receiving and 54 (44-62)% for those not receiving early BCG. On multivariable analysis, early BCG was not significantly associated with recurrence (P= 0.14). The cumulative incidence of progression was ≈10% for both groups, and the cumulative incidence of bladder cancer-specific death was ≈7% for both groups. The cumulative incidence of deferred cystectomy before progression was 14% for those receiving and 15% for those not receiving early BCG. Conclusion S There is a significant variability among surgeons in the management of patients with T1 disease. The similar outcome for the BCG-treated and-untreated patients in our study is most likely confounded by patient selection.

AB - Objectives: To report the heterogeneity in the treatment of patients with cT1 urothelial carcinoma by different surgeons, and to report outcomes in patients with and without bacillus Calmette-Guérin (BCG) treatment. Patients and Methods We retrospectively reviewed 396 patients who had undergone a re-staging transurethral resection (TUR) for cT1 bladder cancer. We assessed both differences in the treatment by surgeon, and the association of early treatment with BCG with recurrence, progression and bladder cancer-specific death. Results: Muscle was captured in the re-staging TUR specimen in a median of 76% of patients (range 50-94 when stratified by surgeon). On multivariable analysis there was significant heterogeneity among surgeons in the use of early cystectomy (P < 0.001), deferred cystectomy (P < 0.001), and BCG (P= 0.014). However, there was no significant heterogeneity between surgeons in clinical outcome for recurrence (P= 0.9) and overall survival (P= 0.3). Among 288 patients placed on surveillance, the 5-year probability (95% confidence interval) of freedom from recurrence was 45 (36-54)% for those receiving and 54 (44-62)% for those not receiving early BCG. On multivariable analysis, early BCG was not significantly associated with recurrence (P= 0.14). The cumulative incidence of progression was ≈10% for both groups, and the cumulative incidence of bladder cancer-specific death was ≈7% for both groups. The cumulative incidence of deferred cystectomy before progression was 14% for those receiving and 15% for those not receiving early BCG. Conclusion S There is a significant variability among surgeons in the management of patients with T1 disease. The similar outcome for the BCG-treated and-untreated patients in our study is most likely confounded by patient selection.

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