Variable association of DNA polymerase with the cytoskeletal fractions of resting and dividing cells

Usha K. Srinivas, C. S. Shashikant, M. R. Das

Research output: Contribution to journalArticle

Abstract

A DNA polymerase activity associated with the detergent insoluble cytoskeletal fraction has been identified in dividing and non-dividing rat hepatocytes and a hepatoma (the Zajdela Ascitic Hepatoma). About 35 % of the enzyme is found associated with the cytoskeletal fraction of non-dividing cells as compared to about 3-6 % of the enzyme in dividing cells even though the dividing cells contain larger amounts of the extranuclear enzyme. The properties of the enzyme are similar to those of DNA polymerase-v. It is suggested that the association of the enzyme with the cytoskeletal fraction has functional significance.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalJournal of Biosciences
Volume9
Issue number3-4
DOIs
StatePublished - Dec 1 1985

Fingerprint

DNA-directed DNA polymerase
DNA-Directed DNA Polymerase
Enzymes
enzymes
hepatoma
cells
Hepatocellular Carcinoma
detergents
Detergents
hepatocytes
Rats
Hepatocytes
rats

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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title = "Variable association of DNA polymerase with the cytoskeletal fractions of resting and dividing cells",
abstract = "A DNA polymerase activity associated with the detergent insoluble cytoskeletal fraction has been identified in dividing and non-dividing rat hepatocytes and a hepatoma (the Zajdela Ascitic Hepatoma). About 35 {\%} of the enzyme is found associated with the cytoskeletal fraction of non-dividing cells as compared to about 3-6 {\%} of the enzyme in dividing cells even though the dividing cells contain larger amounts of the extranuclear enzyme. The properties of the enzyme are similar to those of DNA polymerase-v. It is suggested that the association of the enzyme with the cytoskeletal fraction has functional significance.",
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Variable association of DNA polymerase with the cytoskeletal fractions of resting and dividing cells. / Srinivas, Usha K.; Shashikant, C. S.; Das, M. R.

In: Journal of Biosciences, Vol. 9, No. 3-4, 01.12.1985, p. 231-236.

Research output: Contribution to journalArticle

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