Variable manifestations of familial hemiplegic migraine associated with reversible cerebral edema in children

Sheila Asghar, Alessandra Milesi-Hallé, Chavvi Kaushik, Charles Glasier, Gregory B. Sharp

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Three children with familial hemiplegic migraine presented with right-sided weakness, speech difficulty, altered mental status, and gait abnormalities. These persistent aura signs were accompanied by left-sided slowing and cerebral dysfunction, documented by electroencephalograms. Cranial magnetic resonance imaging revealed cortical edema restricted to the left cerebral hemisphere. Follow-up electroencephalogram and imaging studies produced normal results 1-4 months afterward. However, cognitive changes persisted. Genetic testing demonstrated variable results: one child manifested a CACNA1A mutation compatible with familial hemiplegic migraine type 1, whereas another demonstrated an ATP1A2 sequence alteration. No known mutations were evident in the third child, with minor head trauma thought to precipitate the familial hemiplegic migraine. These findings demonstrate the variable clinical and genetic heterogeneity of childhood familial hemiplegic migraine.

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalPediatric Neurology
Volume47
Issue number3
DOIs
StatePublished - Sep 1 2012

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

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