Interactions of water and nitrogen (N) supply for crop production can be quite complex across field landscapes. The availability of variable rate fertilization systems, and now variable rate irrigation systems, gives crop producers the opportunity to adjust inputs of water and N according to variation in soil properties. A study conducted across Nebraska, USA, evaluated interactions of water and N supply with landscape features for irrigated maize in 2011 and 2012. Crop yield response to treatments varied with year, as 2012 experienced severe drought conditions. There was evidence from one site/year that irrigation water use efficiency and agronomic efficiency were correlated, with lower productivity areas of fields requiring different levels of water and N than more productive areas.