Vascular and neural basis of the BOLD signal

Research output: Contribution to journalReview article

Abstract

Neural activity in the brain is usually coupled to increases in local cerebral blood flow, leading to the increase in oxygenation that generates the BOLD fMRI signal. Recent work has begun to elucidate the vascular and neural mechanisms underlying the BOLD signal. The dilatory response is distributed throughout the vascular network. Arteries actively dilate within a second following neural activity increases, while venous distensions are passive and have a time course that last tens of seconds. Vasodilation, and thus local blood flow, is controlled by the activity of both neurons and astrocytes via multiple different pathways. The relationship between sensory-driven neural activity and the vascular dynamics in sensory areas are well-captured with a linear convolution model. However, depending on the behavioral state or brain region, the coupling between neural activity and hemodynamic signals can be weak or even inverted.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalCurrent Opinion in Neurobiology
Volume58
DOIs
StatePublished - Oct 2019

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Blood Vessels
Cerebrovascular Circulation
Brain
Vasodilation
Astrocytes
Linear Models
Arteries
Hemodynamics
Magnetic Resonance Imaging
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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title = "Vascular and neural basis of the BOLD signal",
abstract = "Neural activity in the brain is usually coupled to increases in local cerebral blood flow, leading to the increase in oxygenation that generates the BOLD fMRI signal. Recent work has begun to elucidate the vascular and neural mechanisms underlying the BOLD signal. The dilatory response is distributed throughout the vascular network. Arteries actively dilate within a second following neural activity increases, while venous distensions are passive and have a time course that last tens of seconds. Vasodilation, and thus local blood flow, is controlled by the activity of both neurons and astrocytes via multiple different pathways. The relationship between sensory-driven neural activity and the vascular dynamics in sensory areas are well-captured with a linear convolution model. However, depending on the behavioral state or brain region, the coupling between neural activity and hemodynamic signals can be weak or even inverted.",
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Vascular and neural basis of the BOLD signal. / Drew, Patrick J.

In: Current Opinion in Neurobiology, Vol. 58, 10.2019, p. 61-69.

Research output: Contribution to journalReview article

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