Vascular Structure and Function in Women. Relationship with Body Mass Index

Thomas P. Olson, Kathryn H. Schmitz, Arthur S. Leon, Donald R. Dengel

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: The purpose of the present study was to compare endothelial function in lean (body mass index [BMI] = 18.0-24.9 kg/m2); overweight (BMI = 25-29.9 kg/m2); and obese (BMI >30 kg/m2), healthy, eumenorrheic women. Methods: Eighteen lean, 22 overweight, and 19 obese eumenorrheic middle-aged women were studied. Vascular structure and function were assessed via non-invasive ultrasound imaging of the carotid and brachial arteries. Body composition, blood pressure, fasting blood lipids, glucose, and insulin also were measured. Results: The groups demonstrated significantly (p<0.001) different mean values for total body, lean body, and fat masses. The obese group demonstrated significantly (p<0.05) elevated fasting glucose and insulin levels and lower high-density lipoprotein levels as compared to the lean group. The overweight group also demonstrated elevated fasting glucose levels as compared to the lean group (p<0.05) with no significant difference from the obese group. Only systolic blood pressure differed among the three groups, being elevated in the obese group compared to the lean group (p<0.05). The obese group demonstrated significantly (p<0.05) elevated carotid artery lumen diameter, carotid artery wall cross-sectional area, and brachial artery lumen diameter with significantly (p<0.05) lower flow-mediated dilation as compared to the lean group. The overweight group demonstrated elevated carotid artery wall cross-sectional area and brachial artery lumen diameter as well as lower flow-mediated dilation as compared to the lean group (p<0.05). Conclusions: The results of this study support the hypothesis that carotid artery wall cross-sectional area is elevated and flow-mediated dilation reduced in overweight and obese eumennorheic women as compared to lean counterparts in relation to BMI classification.

Original languageEnglish (US)
Pages (from-to)487-492
Number of pages6
JournalAmerican Journal of Preventive Medicine
Volume30
Issue number6
DOIs
StatePublished - Jun 1 2006

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Carotid Arteries
Blood Vessels
Body Mass Index
Brachial Artery
Dilatation
Fasting
Blood Pressure
Insulin
Glucose
HDL Lipoproteins
Body Composition
Blood Glucose
Adipose Tissue
Ultrasonography
Lipids

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Olson, Thomas P. ; Schmitz, Kathryn H. ; Leon, Arthur S. ; Dengel, Donald R. / Vascular Structure and Function in Women. Relationship with Body Mass Index. In: American Journal of Preventive Medicine. 2006 ; Vol. 30, No. 6. pp. 487-492.
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Vascular Structure and Function in Women. Relationship with Body Mass Index. / Olson, Thomas P.; Schmitz, Kathryn H.; Leon, Arthur S.; Dengel, Donald R.

In: American Journal of Preventive Medicine, Vol. 30, No. 6, 01.06.2006, p. 487-492.

Research output: Contribution to journalArticle

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