Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma

D. M. Judge, Laurence Demers, D. L. Nahrwold, P. S. Dickman, R. J. Petrokubi, S. Trapukdi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A 61-yr-old woman had watery diarhea, hypochlorhydria, hypokalemia, and elevated serum gastrin levels. She had islet cell carcinoma of the body of the pancreas with multiple metastases to the liver. Radioimmunoassay and immunofluorescence demonstrated both vasoactive intestinal polypeptide (VIP) and gastrin in the surgically removed carcinoma and in a metastatic focus. Electron microscopical findings confirmed the presence of 2 cell types whose secretory granules had characteristics ascribed to these two hormones. Plasma prostaglandin E levels were also elevated above normal. Serum VIP levels became elevated to the Verner-Morrison range prior to her death of a bleeding duodenal ulcer two years after initial symptoms.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume101
Issue number5
StatePublished - Dec 1 1977

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Islet Cell Carcinoma
Vasoactive Intestinal Peptide
Gastrins
Achlorhydria
Hypokalemia
Secretory Vesicles
Duodenal Ulcer
Prostaglandins E
Serum
Radioimmunoassay
Fluorescent Antibody Technique
Pancreas
Hormones
Electrons
Hemorrhage
Neoplasm Metastasis
Carcinoma
Liver

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Judge, D. M., Demers, L., Nahrwold, D. L., Dickman, P. S., Petrokubi, R. J., & Trapukdi, S. (1977). Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma. Archives of Pathology and Laboratory Medicine, 101(5), 262-265.
Judge, D. M. ; Demers, Laurence ; Nahrwold, D. L. ; Dickman, P. S. ; Petrokubi, R. J. ; Trapukdi, S. / Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma. In: Archives of Pathology and Laboratory Medicine. 1977 ; Vol. 101, No. 5. pp. 262-265.
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Judge, DM, Demers, L, Nahrwold, DL, Dickman, PS, Petrokubi, RJ & Trapukdi, S 1977, 'Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma', Archives of Pathology and Laboratory Medicine, vol. 101, no. 5, pp. 262-265.

Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma. / Judge, D. M.; Demers, Laurence; Nahrwold, D. L.; Dickman, P. S.; Petrokubi, R. J.; Trapukdi, S.

In: Archives of Pathology and Laboratory Medicine, Vol. 101, No. 5, 01.12.1977, p. 262-265.

Research output: Contribution to journalArticle

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AB - A 61-yr-old woman had watery diarhea, hypochlorhydria, hypokalemia, and elevated serum gastrin levels. She had islet cell carcinoma of the body of the pancreas with multiple metastases to the liver. Radioimmunoassay and immunofluorescence demonstrated both vasoactive intestinal polypeptide (VIP) and gastrin in the surgically removed carcinoma and in a metastatic focus. Electron microscopical findings confirmed the presence of 2 cell types whose secretory granules had characteristics ascribed to these two hormones. Plasma prostaglandin E levels were also elevated above normal. Serum VIP levels became elevated to the Verner-Morrison range prior to her death of a bleeding duodenal ulcer two years after initial symptoms.

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Judge DM, Demers L, Nahrwold DL, Dickman PS, Petrokubi RJ, Trapukdi S. Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma. Archives of Pathology and Laboratory Medicine. 1977 Dec 1;101(5):262-265.