Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure

Mary E.J. Lott, Cynthia Hogeman, Michael Herr, Monica Bhagat, Allen Kunselman, Lawrence I. Sinoway

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The purpose of this study was to examine upper and lower limb vasoconstrictor responses to changes in transmural pressure in humans. Brachial and femoral blood mean blood velocity (MBV) and vessel diameter (Doppler ultrasound) were measured in 20 supine healthy subjects (10 men and 10 women; 27 ± 1 yr; mean ± SE) during four levels of limb suction at -25, -50, -75, and -100 mmHg, respectively. Limb suction led to an initial rise in MBV followed by a rapid fall in flow velocity to a level below MBV baseline, indicating a vasoconstriction effect. Femoral compared with brachial vessels exhibited a greater fall in flow velocity at all levels of suction ( - 89 ± 17 vs. -10 ± 2, -142 ± 11 vs. -14 ± 2, -156 ± 22 vs. -13 ± 2, and -162 ± 29 vs. -12 ± 2 ml/min for - 25, - 50, - 75, and - 100 mmHg, respectively; interaction effect, P < 0.05). Even at low tank suction levels (i.e., -10 and -20 mmHg), significant brachial flow velocity vasoconstriction from baseline values was demonstrated, reflecting downstream resistance vessel changes (n = 14). Brachial and femoral diameters did not change during changes in negative tank pressure. During suction, changes in limb volumes were significantly greater in the forearm (1.4 ± 0.5%, 2.4 ± 0.8%, 3.5 ± 1.0%, and 4.3 ± 1.1%) compared with the calf (0.9 ± 0.5%, 1.4 ± 0.7%, 2.0 ± 0.8%, and 2.8 ± 1.1%) at all levels of negative tank pressures (- 25, - 50, - 75, and - 100 mmHg, respectively). Simultaneous measurements of both upper limbs and both lower limbs suggested that the majority of the reduction in flow was due to myogenic influences except when -100 mmHg of suction was applied to the lower limb. The greater vaso-constriction responses in the leg compared with the arm with suction appear to be influenced by both myogenic and sympathetic mechanisms.

Original languageEnglish (US)
Pages (from-to)302-310
Number of pages9
JournalJournal of applied physiology
Volume106
Issue number1
DOIs
StatePublished - Jan 1 2009

Fingerprint

Suction
Vasoconstrictor Agents
Lower Extremity
Pressure
Arm
Thigh
Extremities
Vasoconstriction
Doppler Ultrasonography
Forearm
Constriction
Upper Extremity
Blood Vessels
Leg
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Lott, Mary E.J. ; Hogeman, Cynthia ; Herr, Michael ; Bhagat, Monica ; Kunselman, Allen ; Sinoway, Lawrence I. / Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure. In: Journal of applied physiology. 2009 ; Vol. 106, No. 1. pp. 302-310.
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abstract = "The purpose of this study was to examine upper and lower limb vasoconstrictor responses to changes in transmural pressure in humans. Brachial and femoral blood mean blood velocity (MBV) and vessel diameter (Doppler ultrasound) were measured in 20 supine healthy subjects (10 men and 10 women; 27 ± 1 yr; mean ± SE) during four levels of limb suction at -25, -50, -75, and -100 mmHg, respectively. Limb suction led to an initial rise in MBV followed by a rapid fall in flow velocity to a level below MBV baseline, indicating a vasoconstriction effect. Femoral compared with brachial vessels exhibited a greater fall in flow velocity at all levels of suction ( - 89 ± 17 vs. -10 ± 2, -142 ± 11 vs. -14 ± 2, -156 ± 22 vs. -13 ± 2, and -162 ± 29 vs. -12 ± 2 ml/min for - 25, - 50, - 75, and - 100 mmHg, respectively; interaction effect, P < 0.05). Even at low tank suction levels (i.e., -10 and -20 mmHg), significant brachial flow velocity vasoconstriction from baseline values was demonstrated, reflecting downstream resistance vessel changes (n = 14). Brachial and femoral diameters did not change during changes in negative tank pressure. During suction, changes in limb volumes were significantly greater in the forearm (1.4 ± 0.5{\%}, 2.4 ± 0.8{\%}, 3.5 ± 1.0{\%}, and 4.3 ± 1.1{\%}) compared with the calf (0.9 ± 0.5{\%}, 1.4 ± 0.7{\%}, 2.0 ± 0.8{\%}, and 2.8 ± 1.1{\%}) at all levels of negative tank pressures (- 25, - 50, - 75, and - 100 mmHg, respectively). Simultaneous measurements of both upper limbs and both lower limbs suggested that the majority of the reduction in flow was due to myogenic influences except when -100 mmHg of suction was applied to the lower limb. The greater vaso-constriction responses in the leg compared with the arm with suction appear to be influenced by both myogenic and sympathetic mechanisms.",
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Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure. / Lott, Mary E.J.; Hogeman, Cynthia; Herr, Michael; Bhagat, Monica; Kunselman, Allen; Sinoway, Lawrence I.

In: Journal of applied physiology, Vol. 106, No. 1, 01.01.2009, p. 302-310.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure

AU - Lott, Mary E.J.

AU - Hogeman, Cynthia

AU - Herr, Michael

AU - Bhagat, Monica

AU - Kunselman, Allen

AU - Sinoway, Lawrence I.

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N2 - The purpose of this study was to examine upper and lower limb vasoconstrictor responses to changes in transmural pressure in humans. Brachial and femoral blood mean blood velocity (MBV) and vessel diameter (Doppler ultrasound) were measured in 20 supine healthy subjects (10 men and 10 women; 27 ± 1 yr; mean ± SE) during four levels of limb suction at -25, -50, -75, and -100 mmHg, respectively. Limb suction led to an initial rise in MBV followed by a rapid fall in flow velocity to a level below MBV baseline, indicating a vasoconstriction effect. Femoral compared with brachial vessels exhibited a greater fall in flow velocity at all levels of suction ( - 89 ± 17 vs. -10 ± 2, -142 ± 11 vs. -14 ± 2, -156 ± 22 vs. -13 ± 2, and -162 ± 29 vs. -12 ± 2 ml/min for - 25, - 50, - 75, and - 100 mmHg, respectively; interaction effect, P < 0.05). Even at low tank suction levels (i.e., -10 and -20 mmHg), significant brachial flow velocity vasoconstriction from baseline values was demonstrated, reflecting downstream resistance vessel changes (n = 14). Brachial and femoral diameters did not change during changes in negative tank pressure. During suction, changes in limb volumes were significantly greater in the forearm (1.4 ± 0.5%, 2.4 ± 0.8%, 3.5 ± 1.0%, and 4.3 ± 1.1%) compared with the calf (0.9 ± 0.5%, 1.4 ± 0.7%, 2.0 ± 0.8%, and 2.8 ± 1.1%) at all levels of negative tank pressures (- 25, - 50, - 75, and - 100 mmHg, respectively). Simultaneous measurements of both upper limbs and both lower limbs suggested that the majority of the reduction in flow was due to myogenic influences except when -100 mmHg of suction was applied to the lower limb. The greater vaso-constriction responses in the leg compared with the arm with suction appear to be influenced by both myogenic and sympathetic mechanisms.

AB - The purpose of this study was to examine upper and lower limb vasoconstrictor responses to changes in transmural pressure in humans. Brachial and femoral blood mean blood velocity (MBV) and vessel diameter (Doppler ultrasound) were measured in 20 supine healthy subjects (10 men and 10 women; 27 ± 1 yr; mean ± SE) during four levels of limb suction at -25, -50, -75, and -100 mmHg, respectively. Limb suction led to an initial rise in MBV followed by a rapid fall in flow velocity to a level below MBV baseline, indicating a vasoconstriction effect. Femoral compared with brachial vessels exhibited a greater fall in flow velocity at all levels of suction ( - 89 ± 17 vs. -10 ± 2, -142 ± 11 vs. -14 ± 2, -156 ± 22 vs. -13 ± 2, and -162 ± 29 vs. -12 ± 2 ml/min for - 25, - 50, - 75, and - 100 mmHg, respectively; interaction effect, P < 0.05). Even at low tank suction levels (i.e., -10 and -20 mmHg), significant brachial flow velocity vasoconstriction from baseline values was demonstrated, reflecting downstream resistance vessel changes (n = 14). Brachial and femoral diameters did not change during changes in negative tank pressure. During suction, changes in limb volumes were significantly greater in the forearm (1.4 ± 0.5%, 2.4 ± 0.8%, 3.5 ± 1.0%, and 4.3 ± 1.1%) compared with the calf (0.9 ± 0.5%, 1.4 ± 0.7%, 2.0 ± 0.8%, and 2.8 ± 1.1%) at all levels of negative tank pressures (- 25, - 50, - 75, and - 100 mmHg, respectively). Simultaneous measurements of both upper limbs and both lower limbs suggested that the majority of the reduction in flow was due to myogenic influences except when -100 mmHg of suction was applied to the lower limb. The greater vaso-constriction responses in the leg compared with the arm with suction appear to be influenced by both myogenic and sympathetic mechanisms.

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