Vegetable organosulfur compounds and their health promoting effects

Spyridon Petropoulos, Francesco Di Gioia, Georgia Ntatsi

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Background: Trends in modern pharmaceutical science show an increase in demand for new drugs and diet supplements derived from natural products, while during the last decades, great research is conducted regarding the natural compounds and their medicinal and bioactive properties. Organosulfur compounds are present in many plants and their bioactive properties have been used in folk and traditional medicine throughout the centuries. Not until recently, modern science confirmed and revealed the chemical compounds that are responsible for these properties, the chemistry involved in their biosynthesis and the main mechanisms of action. Objective: In the present review, the organosulfur compounds of vegetable origin and their health effects are presented, focusing on the chemical composition of their main compounds, their biosynthesis and the mechanisms involved in their health effects. Sulfur compound sources presented include mainly vegetable species belonging to Allium genus and Brassicaceae family. Conclusion: Organosulfur compounds of vegetable sources are very important in human diet, and their regular consumption has a beneficial contribution to health and well-being. Moreover, their medicinal properties and therapeutic effects have been described thousands of years ago, while they constitute an important ingredient in traditional medicines and preparations. However, not until recently, the mechanisms of action of organosulfur compounds have started to unravel, with promising results for further exploitation of these significant bioactive compounds in drug development and novel nutraceutical products. This review reveals the numerous biological activities of organosulfur compounds of vegetable origin, while it also presents the results of recent clinical studies and trials.

Original languageEnglish (US)
Pages (from-to)2850-2875
Number of pages26
JournalCurrent Pharmaceutical Design
Volume23
Issue number19
DOIs
StatePublished - May 1 2017

Fingerprint

Vegetables
Traditional Medicine
Health
Pharmaceutical Preparations
Allium
Brassicaceae
Diet
Sulfur Compounds
Therapeutic Uses
Dietary Supplements
Biological Products
Clinical Trials
Research

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Petropoulos, Spyridon ; Di Gioia, Francesco ; Ntatsi, Georgia. / Vegetable organosulfur compounds and their health promoting effects. In: Current Pharmaceutical Design. 2017 ; Vol. 23, No. 19. pp. 2850-2875.
@article{9527412ce3604ef99e0c69a5d126dce2,
title = "Vegetable organosulfur compounds and their health promoting effects",
abstract = "Background: Trends in modern pharmaceutical science show an increase in demand for new drugs and diet supplements derived from natural products, while during the last decades, great research is conducted regarding the natural compounds and their medicinal and bioactive properties. Organosulfur compounds are present in many plants and their bioactive properties have been used in folk and traditional medicine throughout the centuries. Not until recently, modern science confirmed and revealed the chemical compounds that are responsible for these properties, the chemistry involved in their biosynthesis and the main mechanisms of action. Objective: In the present review, the organosulfur compounds of vegetable origin and their health effects are presented, focusing on the chemical composition of their main compounds, their biosynthesis and the mechanisms involved in their health effects. Sulfur compound sources presented include mainly vegetable species belonging to Allium genus and Brassicaceae family. Conclusion: Organosulfur compounds of vegetable sources are very important in human diet, and their regular consumption has a beneficial contribution to health and well-being. Moreover, their medicinal properties and therapeutic effects have been described thousands of years ago, while they constitute an important ingredient in traditional medicines and preparations. However, not until recently, the mechanisms of action of organosulfur compounds have started to unravel, with promising results for further exploitation of these significant bioactive compounds in drug development and novel nutraceutical products. This review reveals the numerous biological activities of organosulfur compounds of vegetable origin, while it also presents the results of recent clinical studies and trials.",
author = "Spyridon Petropoulos and {Di Gioia}, Francesco and Georgia Ntatsi",
year = "2017",
month = "5",
day = "1",
doi = "10.2174/1381612823666170111100531",
language = "English (US)",
volume = "23",
pages = "2850--2875",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers B.V.",
number = "19",

}

Vegetable organosulfur compounds and their health promoting effects. / Petropoulos, Spyridon; Di Gioia, Francesco; Ntatsi, Georgia.

In: Current Pharmaceutical Design, Vol. 23, No. 19, 01.05.2017, p. 2850-2875.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Vegetable organosulfur compounds and their health promoting effects

AU - Petropoulos, Spyridon

AU - Di Gioia, Francesco

AU - Ntatsi, Georgia

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background: Trends in modern pharmaceutical science show an increase in demand for new drugs and diet supplements derived from natural products, while during the last decades, great research is conducted regarding the natural compounds and their medicinal and bioactive properties. Organosulfur compounds are present in many plants and their bioactive properties have been used in folk and traditional medicine throughout the centuries. Not until recently, modern science confirmed and revealed the chemical compounds that are responsible for these properties, the chemistry involved in their biosynthesis and the main mechanisms of action. Objective: In the present review, the organosulfur compounds of vegetable origin and their health effects are presented, focusing on the chemical composition of their main compounds, their biosynthesis and the mechanisms involved in their health effects. Sulfur compound sources presented include mainly vegetable species belonging to Allium genus and Brassicaceae family. Conclusion: Organosulfur compounds of vegetable sources are very important in human diet, and their regular consumption has a beneficial contribution to health and well-being. Moreover, their medicinal properties and therapeutic effects have been described thousands of years ago, while they constitute an important ingredient in traditional medicines and preparations. However, not until recently, the mechanisms of action of organosulfur compounds have started to unravel, with promising results for further exploitation of these significant bioactive compounds in drug development and novel nutraceutical products. This review reveals the numerous biological activities of organosulfur compounds of vegetable origin, while it also presents the results of recent clinical studies and trials.

AB - Background: Trends in modern pharmaceutical science show an increase in demand for new drugs and diet supplements derived from natural products, while during the last decades, great research is conducted regarding the natural compounds and their medicinal and bioactive properties. Organosulfur compounds are present in many plants and their bioactive properties have been used in folk and traditional medicine throughout the centuries. Not until recently, modern science confirmed and revealed the chemical compounds that are responsible for these properties, the chemistry involved in their biosynthesis and the main mechanisms of action. Objective: In the present review, the organosulfur compounds of vegetable origin and their health effects are presented, focusing on the chemical composition of their main compounds, their biosynthesis and the mechanisms involved in their health effects. Sulfur compound sources presented include mainly vegetable species belonging to Allium genus and Brassicaceae family. Conclusion: Organosulfur compounds of vegetable sources are very important in human diet, and their regular consumption has a beneficial contribution to health and well-being. Moreover, their medicinal properties and therapeutic effects have been described thousands of years ago, while they constitute an important ingredient in traditional medicines and preparations. However, not until recently, the mechanisms of action of organosulfur compounds have started to unravel, with promising results for further exploitation of these significant bioactive compounds in drug development and novel nutraceutical products. This review reveals the numerous biological activities of organosulfur compounds of vegetable origin, while it also presents the results of recent clinical studies and trials.

UR - http://www.scopus.com/inward/record.url?scp=85027863794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027863794&partnerID=8YFLogxK

U2 - 10.2174/1381612823666170111100531

DO - 10.2174/1381612823666170111100531

M3 - Review article

VL - 23

SP - 2850

EP - 2875

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 19

ER -