Ventilatory and gas exchange response during walking in severe peripheral vascular disease

P. Haouzi, J. J. Hirsch, F. Marchal, A. Huszczuk

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It has long been recognized that at the onset of a dynamic muscular exercise the ventilatory and the circulatory (blood flow) responses appear to be matched, thereby maintaining arterial blood gas homeostasis. Such a coupling has recently been suggested to rely upon ventilatory reflex triggered by mechanoreceptors encoding changes in muscle blood flow or, more likely, blood volume. The aim of this study was to investigate whether patients with severe peripheral blood flow limitation to the lower extremities have a normal ventilatory response during a light intensity exercise. The ventilatory and gas exchange temporal response characteristics were studied during a 6 min walking test in seven patients with severe ischemic peripheral vascular disease and in six normal age-matched subjects. The magnitude of the overall ventilatory and V̇(O2) increment at the end of the tests was similar in both groups. However, in contrast to the control subjects, who presented an almost rectangular response, the patients had a considerably slowed response dynamics (t50 = 33 ± 4 vs. 9 ± 3 sec for V̇(O2) and 37 ± 5 vs. 10 ± 8 sec for V̇E) with a dramatic reduction in the magnitude of the initial 20 sec of the responses. Although the slow V̇(O2) dynamics in patients presumably reflected the impeded perfusion of the working muscles, the accompanying sluggishness of the V̇(E course) implies that either muscular ischemia actually inhibits ventilatory response to exercise or, more likely, that this response is strongly linked to the magnitude of the hyperemia in the exercising muscles.

Original languageEnglish (US)
Pages (from-to)181-190
Number of pages10
JournalRespiration Physiology
Volume107
Issue number2
DOIs
StatePublished - Feb 1 1997

Fingerprint

Peripheral Vascular Diseases
Walking
Gases
Exercise
Muscles
Mechanoreceptors
Hyperemia
Blood Volume
Reflex
Lower Extremity
Homeostasis
Ischemia
Perfusion
Light

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Haouzi, P. ; Hirsch, J. J. ; Marchal, F. ; Huszczuk, A. / Ventilatory and gas exchange response during walking in severe peripheral vascular disease. In: Respiration Physiology. 1997 ; Vol. 107, No. 2. pp. 181-190.
@article{8b6a49e13d1240f5a147dc53013d540e,
title = "Ventilatory and gas exchange response during walking in severe peripheral vascular disease",
abstract = "It has long been recognized that at the onset of a dynamic muscular exercise the ventilatory and the circulatory (blood flow) responses appear to be matched, thereby maintaining arterial blood gas homeostasis. Such a coupling has recently been suggested to rely upon ventilatory reflex triggered by mechanoreceptors encoding changes in muscle blood flow or, more likely, blood volume. The aim of this study was to investigate whether patients with severe peripheral blood flow limitation to the lower extremities have a normal ventilatory response during a light intensity exercise. The ventilatory and gas exchange temporal response characteristics were studied during a 6 min walking test in seven patients with severe ischemic peripheral vascular disease and in six normal age-matched subjects. The magnitude of the overall ventilatory and V̇(O2) increment at the end of the tests was similar in both groups. However, in contrast to the control subjects, who presented an almost rectangular response, the patients had a considerably slowed response dynamics (t50 = 33 ± 4 vs. 9 ± 3 sec for V̇(O2) and 37 ± 5 vs. 10 ± 8 sec for V̇E) with a dramatic reduction in the magnitude of the initial 20 sec of the responses. Although the slow V̇(O2) dynamics in patients presumably reflected the impeded perfusion of the working muscles, the accompanying sluggishness of the V̇(E course) implies that either muscular ischemia actually inhibits ventilatory response to exercise or, more likely, that this response is strongly linked to the magnitude of the hyperemia in the exercising muscles.",
author = "P. Haouzi and Hirsch, {J. J.} and F. Marchal and A. Huszczuk",
year = "1997",
month = "2",
day = "1",
doi = "10.1016/S0034-5687(96)02508-X",
language = "English (US)",
volume = "107",
pages = "181--190",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "2",

}

Ventilatory and gas exchange response during walking in severe peripheral vascular disease. / Haouzi, P.; Hirsch, J. J.; Marchal, F.; Huszczuk, A.

In: Respiration Physiology, Vol. 107, No. 2, 01.02.1997, p. 181-190.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ventilatory and gas exchange response during walking in severe peripheral vascular disease

AU - Haouzi, P.

AU - Hirsch, J. J.

AU - Marchal, F.

AU - Huszczuk, A.

PY - 1997/2/1

Y1 - 1997/2/1

N2 - It has long been recognized that at the onset of a dynamic muscular exercise the ventilatory and the circulatory (blood flow) responses appear to be matched, thereby maintaining arterial blood gas homeostasis. Such a coupling has recently been suggested to rely upon ventilatory reflex triggered by mechanoreceptors encoding changes in muscle blood flow or, more likely, blood volume. The aim of this study was to investigate whether patients with severe peripheral blood flow limitation to the lower extremities have a normal ventilatory response during a light intensity exercise. The ventilatory and gas exchange temporal response characteristics were studied during a 6 min walking test in seven patients with severe ischemic peripheral vascular disease and in six normal age-matched subjects. The magnitude of the overall ventilatory and V̇(O2) increment at the end of the tests was similar in both groups. However, in contrast to the control subjects, who presented an almost rectangular response, the patients had a considerably slowed response dynamics (t50 = 33 ± 4 vs. 9 ± 3 sec for V̇(O2) and 37 ± 5 vs. 10 ± 8 sec for V̇E) with a dramatic reduction in the magnitude of the initial 20 sec of the responses. Although the slow V̇(O2) dynamics in patients presumably reflected the impeded perfusion of the working muscles, the accompanying sluggishness of the V̇(E course) implies that either muscular ischemia actually inhibits ventilatory response to exercise or, more likely, that this response is strongly linked to the magnitude of the hyperemia in the exercising muscles.

AB - It has long been recognized that at the onset of a dynamic muscular exercise the ventilatory and the circulatory (blood flow) responses appear to be matched, thereby maintaining arterial blood gas homeostasis. Such a coupling has recently been suggested to rely upon ventilatory reflex triggered by mechanoreceptors encoding changes in muscle blood flow or, more likely, blood volume. The aim of this study was to investigate whether patients with severe peripheral blood flow limitation to the lower extremities have a normal ventilatory response during a light intensity exercise. The ventilatory and gas exchange temporal response characteristics were studied during a 6 min walking test in seven patients with severe ischemic peripheral vascular disease and in six normal age-matched subjects. The magnitude of the overall ventilatory and V̇(O2) increment at the end of the tests was similar in both groups. However, in contrast to the control subjects, who presented an almost rectangular response, the patients had a considerably slowed response dynamics (t50 = 33 ± 4 vs. 9 ± 3 sec for V̇(O2) and 37 ± 5 vs. 10 ± 8 sec for V̇E) with a dramatic reduction in the magnitude of the initial 20 sec of the responses. Although the slow V̇(O2) dynamics in patients presumably reflected the impeded perfusion of the working muscles, the accompanying sluggishness of the V̇(E course) implies that either muscular ischemia actually inhibits ventilatory response to exercise or, more likely, that this response is strongly linked to the magnitude of the hyperemia in the exercising muscles.

UR - http://www.scopus.com/inward/record.url?scp=0031001673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031001673&partnerID=8YFLogxK

U2 - 10.1016/S0034-5687(96)02508-X

DO - 10.1016/S0034-5687(96)02508-X

M3 - Article

C2 - 9108632

AN - SCOPUS:0031001673

VL - 107

SP - 181

EP - 190

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 2

ER -