Verruciform xanthoma in an immunocompromised patient: a case report and immunohistochemical study

Klaus Helm, R. M. Höpfl, J. W. Kreider, D. P. Lookingbill

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The etiology of verruciform xanthoma, a rare lesion that usually occurs in the oral mucosa, is unknown. A viral etiology has been speculated since extraoral lesions usually occur in the genitalia. We present, to the best of our knowledge, the first reported case of verruciform xanthoma in an immunocompromised patient with chronic graft versus host disease. Immunohistochemical studies showed a few ham 56 (a macrophage marker) positive foam cells, both in the dermis and within the epidermis, supporting a role for an epidermal process in production of the foam cells. Staining for human papillomavirus protein (HPV) showed reactivity of some of the nuclei in the dermal Histiocytes, but in situ hybridization for HPV types 6/11, 16/18, and 31, 33 was negative. These results support an eopidermal process as the stimulus for the foam cell formation but fail to demonstrate HPV as the cause.

Original languageEnglish (US)
Pages (from-to)84-86
Number of pages3
JournalJournal of Cutaneous Pathology
Volume20
Issue number1
DOIs
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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