Versatile routes toward functional, water-soluble nanoparticles via trifluoroethylester-PEG-thiol ligands

Andrew H. Latham, Mary Elizabeth Williams

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

This paper reports the synthesis of a trifluoroethylester-PEG-thiol ligand (TFEE-PEG-SH) and its use to create water-soluble, chemically functional Au metal and FePt magnetic nanoparticles. The trifluoroethylester terminus facilitates attachment of any primary-amine-containing molecule via amide bond formation at room temperature without the use of coupling agents. Three possible routes of nanoparticle functionalization are demonstrated: synthesis of Au nanoparticles in the presence of functionalized R-PEG-SH; ligand-exchange of R-PEG-SH onto both Au and FePt nanoparticles; and exchange of TFEE-PEG-SH onto Au nanoparticles followed by subsequent amide condensation. A series of primary-amine-containing molecules, including biotin and fluorescamine, are easily attached to the water-soluble particles, and the resulting materials are characterized by NMR, UV-visible absorption, and emission spectroscopies.

Original languageEnglish (US)
Pages (from-to)4319-4326
Number of pages8
JournalLangmuir
Volume22
Issue number9
DOIs
StatePublished - Apr 25 2006

Fingerprint

Sulfhydryl Compounds
thiols
Polyethylene glycols
Ligands
routes
Nanoparticles
nanoparticles
ligands
Water
water
Amides
amides
Amines
amines
Fluorescamine
biotin
Molecules
Coupling agents
Emission spectroscopy
synthesis

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

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Versatile routes toward functional, water-soluble nanoparticles via trifluoroethylester-PEG-thiol ligands. / Latham, Andrew H.; Williams, Mary Elizabeth.

In: Langmuir, Vol. 22, No. 9, 25.04.2006, p. 4319-4326.

Research output: Contribution to journalArticle

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