Very Late Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Case Report and Literature Review

Ian Schreibman, P. Bejarano, E. J. Martinez, A. Regev

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Hepatocellular carcinoma (HCC) recurs in 10% to 60% of the patients after liver transplantation (OLT) and is associated with increased mortality. The average time to recurrence ranges from 1 to 2 years following OLT, and the median survival from the time of diagnosis is about 1 year. We report a case of a 69-year-old man who underwent OLT for hepatitis C virus-related cirrhosis with HCC, and was diagnosed with recurrent HCC 6.5 years after OLT. Biopsies from the initial and recurrent tumors showed a well-differentiated HCC with foci of clear cell pattern. The patient was still alive and asymptomatic 32 months after the diagnosis despite extensive tumor burden. He expired 9 years, 9 months after OLT and 3 years, 2 months after the detection of recurrence. In conclusion, HCC may recur more than 6 years after OLT and may exhibit an indolent course. This case illustrates the highly variable rate of tumor growth and progression post-OLT. The impact of this information on the need for long-term surveillance for recurrent HCC post-OLT remains to be determined.

Original languageEnglish (US)
Pages (from-to)3140-3143
Number of pages4
JournalTransplantation Proceedings
Issue number9
StatePublished - Nov 1 2006


All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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