Vesicles protect activated acetic acid

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Methyl thioacetate, or activated acetic acid, has been proposed to be central to the origin of life and an important energy currency molecule in early cellular evolution. We have investigated the hydrolysis of methyl thioacetate under various conditions. Its uncatalyzed rate of hydrolysis is about 3 orders of magnitude faster (K = 0.00663 s-1; 100°C, pH 7.5, concentration = 0.33 mM) than published rates for its catalyzed production, making it unlikely to accumulate under prebiotic conditions. However, our experiments showed that methyl thioacetate was protected from hydrolysis when inside its own hydrophobic droplets. Further, we found that methyl thioacetate protection from hydrolysis was also possible in droplets of hexane and in the membranes of nonanoic acid vesicles. Thus, the hydrophobic regions of prebiotic vesicles and early cell membranes could have offered a refuge for this energetic molecule, increasing its lifetime in close proximity to the reactions for which it would be needed. This model of early energy storage evokes an additional critical function for the earliest cell membranes.

Original languageEnglish (US)
Pages (from-to)859-865
Number of pages7
JournalAstrobiology
Volume14
Issue number10
DOIs
StatePublished - Jan 1 2014

Fingerprint

vesicle
acetic acid
Acetic Acid
hydrolysis
Hydrolysis
Prebiotics
prebiotics
membrane
droplets
droplet
cell membranes
pelargonic acid
Cell Membrane
origin of life
energy
Hexanes
currency
energy storage
hexane
refuge

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences (miscellaneous)
  • Space and Planetary Science

Cite this

Todd, Zoe R. ; House, Christopher H. / Vesicles protect activated acetic acid. In: Astrobiology. 2014 ; Vol. 14, No. 10. pp. 859-865.
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Vesicles protect activated acetic acid. / Todd, Zoe R.; House, Christopher H.

In: Astrobiology, Vol. 14, No. 10, 01.01.2014, p. 859-865.

Research output: Contribution to journalArticle

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AU - Todd, Zoe R.

AU - House, Christopher H.

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N2 - Methyl thioacetate, or activated acetic acid, has been proposed to be central to the origin of life and an important energy currency molecule in early cellular evolution. We have investigated the hydrolysis of methyl thioacetate under various conditions. Its uncatalyzed rate of hydrolysis is about 3 orders of magnitude faster (K = 0.00663 s-1; 100°C, pH 7.5, concentration = 0.33 mM) than published rates for its catalyzed production, making it unlikely to accumulate under prebiotic conditions. However, our experiments showed that methyl thioacetate was protected from hydrolysis when inside its own hydrophobic droplets. Further, we found that methyl thioacetate protection from hydrolysis was also possible in droplets of hexane and in the membranes of nonanoic acid vesicles. Thus, the hydrophobic regions of prebiotic vesicles and early cell membranes could have offered a refuge for this energetic molecule, increasing its lifetime in close proximity to the reactions for which it would be needed. This model of early energy storage evokes an additional critical function for the earliest cell membranes.

AB - Methyl thioacetate, or activated acetic acid, has been proposed to be central to the origin of life and an important energy currency molecule in early cellular evolution. We have investigated the hydrolysis of methyl thioacetate under various conditions. Its uncatalyzed rate of hydrolysis is about 3 orders of magnitude faster (K = 0.00663 s-1; 100°C, pH 7.5, concentration = 0.33 mM) than published rates for its catalyzed production, making it unlikely to accumulate under prebiotic conditions. However, our experiments showed that methyl thioacetate was protected from hydrolysis when inside its own hydrophobic droplets. Further, we found that methyl thioacetate protection from hydrolysis was also possible in droplets of hexane and in the membranes of nonanoic acid vesicles. Thus, the hydrophobic regions of prebiotic vesicles and early cell membranes could have offered a refuge for this energetic molecule, increasing its lifetime in close proximity to the reactions for which it would be needed. This model of early energy storage evokes an additional critical function for the earliest cell membranes.

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