Vi antigen from Salmonella typhosa and immunity against typhoid fever. II. Safety and antigenicity in humans

D. M. Levin, K. H. Wong, H. Y. Reynolds, A. Sutton, R. S. Northrup

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Safety and antigenicity of a purified preparation of Salmonella typhosa Vi antigen was evaluated in human volunteers. Dosages of Vi antigen at 25, 50, and 100 μg were less toxic than U.S. standard typhoid vaccine (lot 6A) containing 5 x 10 8 bacteria oer dosage. Vi antigen in comparison with the standard typhoid vaccine induced higher hemagglutinating antibody but lower bactericidal antibody responses.

Original languageEnglish (US)
Pages (from-to)1290-1294
Number of pages5
JournalInfection and Immunity
Volume12
Issue number6
StatePublished - Dec 1 1975

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Typhoid-Paratyphoid Vaccines
Salmonella typhi
Typhoid Fever
Immunity
Safety
Antigens
Poisons
Antibody Formation
Volunteers
Bacteria
Antibodies

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Levin, D. M., Wong, K. H., Reynolds, H. Y., Sutton, A., & Northrup, R. S. (1975). Vi antigen from Salmonella typhosa and immunity against typhoid fever. II. Safety and antigenicity in humans. Infection and Immunity, 12(6), 1290-1294.
Levin, D. M. ; Wong, K. H. ; Reynolds, H. Y. ; Sutton, A. ; Northrup, R. S. / Vi antigen from Salmonella typhosa and immunity against typhoid fever. II. Safety and antigenicity in humans. In: Infection and Immunity. 1975 ; Vol. 12, No. 6. pp. 1290-1294.
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Levin, DM, Wong, KH, Reynolds, HY, Sutton, A & Northrup, RS 1975, 'Vi antigen from Salmonella typhosa and immunity against typhoid fever. II. Safety and antigenicity in humans', Infection and Immunity, vol. 12, no. 6, pp. 1290-1294.

Vi antigen from Salmonella typhosa and immunity against typhoid fever. II. Safety and antigenicity in humans. / Levin, D. M.; Wong, K. H.; Reynolds, H. Y.; Sutton, A.; Northrup, R. S.

In: Infection and Immunity, Vol. 12, No. 6, 01.12.1975, p. 1290-1294.

Research output: Contribution to journalArticle

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