TY - JOUR
T1 - Vi antigen from Salmonella typhosa and immunity against typhoid fever. II. Safety and antigenicity in humans
AU - Levin, Douglas M.
AU - Wong, Kwei Hay
AU - Reynolds, Herbert Y.
AU - Sutton, Ann
AU - Northrup, Robert S.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1975
Y1 - 1975
N2 - Safety and antigenicity of a purified preparation of Salmonella typhosa Vi antigen was evaluated in human volunteers. Dosages of Vi antigen at 25, 50, and 100 μg were less toxic than U.S. standard typhoid vaccine (lot 6A) containing 5 x 108 bacteria oer dosage. Vi antigen in comparison with the standard typhoid vaccine induced higher hemagglutinating antibody but lower bactericidal antibody responses.
AB - Safety and antigenicity of a purified preparation of Salmonella typhosa Vi antigen was evaluated in human volunteers. Dosages of Vi antigen at 25, 50, and 100 μg were less toxic than U.S. standard typhoid vaccine (lot 6A) containing 5 x 108 bacteria oer dosage. Vi antigen in comparison with the standard typhoid vaccine induced higher hemagglutinating antibody but lower bactericidal antibody responses.
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U2 - 10.1128/iai.12.6.1290-1294.1975
DO - 10.1128/iai.12.6.1290-1294.1975
M3 - Article
C2 - 54336
AN - SCOPUS:0016761730
VL - 12
SP - 1290
EP - 1294
JO - [No source information available]
JF - [No source information available]
SN - 0042-1215
IS - 6
ER -