Vilsmeier reagent, NaHSe and diclofenac acid chloride: One-pot synthesis of a novel selenoindolinone with potent anticancer activity

Ana Carolina Ruberte, Carlos Aydillo, Arun K. Sharma, Carmen Sanmartín, Daniel Plano

Research output: Contribution to journalArticlepeer-review

Abstract

An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.

Original languageEnglish (US)
Pages (from-to)38404-38408
Number of pages5
JournalRSC Advances
Volume10
Issue number63
DOIs
StatePublished - Oct 19 2020

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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