Viral and bacterial aetiologies of epithelial ovarian cancer

Shanmughapriya Santhanam, N. Vasanthi, G. SenthilKumar, S. Shanmughapriya, K. Vinodhini, K. Natarajaseenivasan, B. C. Das

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We sought to analyse the presence of human papillomavirus (HPV), Chlamydia trachomatis and cytomegalovirus (CMV) infection in women with epithelial ovarian carcinomas. Polymerase chain reaction (PCR)-based detection of microbial infections was carried out. A total of 39 tissue samples were analysed with consensus and type-specific primers for HPV, primers specific for the cryptic plasmid of Chlamydia and primers for glycoprotein B of CMV. The samples analysed showed 40%, 80% and 50% positivity for HPV, Chlamydia and CMV infection, respectively, in cancerous ovarian tissues. The HPV type detected was HPV 6, with its genome integrated to the host genome in case of both invasive and borderline tumours and existed episomally in healthy controls. The patients with Chlamydia (odds ratio [OR] 32; 95% confidence interval [CI] 3.33, 307.65) and CMV infection (OR 8; 95% CI 0.888, 72.10) are at significantly higher risk of development of ovarian tumours. The present study validates the theory of chronic infections and inflammation in the pathogenesis of epithelial ovarian cancer. Further seroepidemiological studies and large fresh tissue sampling may represent the real prevalence of infections among ovarian carcinoma patients. This study is the first of its kind in detecting the bacterial and viral aetiologies in the development of ovarian carcinoma among Indian women.

Original languageEnglish (US)
Pages (from-to)2311-2317
Number of pages7
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume31
Issue number9
DOIs
StatePublished - Sep 1 2012

Fingerprint

Cytomegalovirus Infections
Chlamydia Infections
Chlamydia
Carcinoma
Infection
Odds Ratio
Genome
Confidence Intervals
Human papillomavirus 6
Papillomavirus Infections
Chlamydia trachomatis
Seroepidemiologic Studies
Neoplasms
Plasmids
Inflammation
Polymerase Chain Reaction
Ovarian epithelial cancer

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Santhanam, S., Vasanthi, N., SenthilKumar, G., Shanmughapriya, S., Vinodhini, K., Natarajaseenivasan, K., & Das, B. C. (2012). Viral and bacterial aetiologies of epithelial ovarian cancer. European Journal of Clinical Microbiology and Infectious Diseases, 31(9), 2311-2317. https://doi.org/10.1007/s10096-012-1570-5
Santhanam, Shanmughapriya ; Vasanthi, N. ; SenthilKumar, G. ; Shanmughapriya, S. ; Vinodhini, K. ; Natarajaseenivasan, K. ; Das, B. C. / Viral and bacterial aetiologies of epithelial ovarian cancer. In: European Journal of Clinical Microbiology and Infectious Diseases. 2012 ; Vol. 31, No. 9. pp. 2311-2317.
@article{057bf39664654a178c7f50d3c86a8d6b,
title = "Viral and bacterial aetiologies of epithelial ovarian cancer",
abstract = "We sought to analyse the presence of human papillomavirus (HPV), Chlamydia trachomatis and cytomegalovirus (CMV) infection in women with epithelial ovarian carcinomas. Polymerase chain reaction (PCR)-based detection of microbial infections was carried out. A total of 39 tissue samples were analysed with consensus and type-specific primers for HPV, primers specific for the cryptic plasmid of Chlamydia and primers for glycoprotein B of CMV. The samples analysed showed 40{\%}, 80{\%} and 50{\%} positivity for HPV, Chlamydia and CMV infection, respectively, in cancerous ovarian tissues. The HPV type detected was HPV 6, with its genome integrated to the host genome in case of both invasive and borderline tumours and existed episomally in healthy controls. The patients with Chlamydia (odds ratio [OR] 32; 95{\%} confidence interval [CI] 3.33, 307.65) and CMV infection (OR 8; 95{\%} CI 0.888, 72.10) are at significantly higher risk of development of ovarian tumours. The present study validates the theory of chronic infections and inflammation in the pathogenesis of epithelial ovarian cancer. Further seroepidemiological studies and large fresh tissue sampling may represent the real prevalence of infections among ovarian carcinoma patients. This study is the first of its kind in detecting the bacterial and viral aetiologies in the development of ovarian carcinoma among Indian women.",
author = "Shanmughapriya Santhanam and N. Vasanthi and G. SenthilKumar and S. Shanmughapriya and K. Vinodhini and K. Natarajaseenivasan and Das, {B. C.}",
year = "2012",
month = "9",
day = "1",
doi = "10.1007/s10096-012-1570-5",
language = "English (US)",
volume = "31",
pages = "2311--2317",
journal = "European Journal of Clinical Microbiology and Infectious Diseases",
issn = "0934-9723",
publisher = "Springer Verlag",
number = "9",

}

Santhanam, S, Vasanthi, N, SenthilKumar, G, Shanmughapriya, S, Vinodhini, K, Natarajaseenivasan, K & Das, BC 2012, 'Viral and bacterial aetiologies of epithelial ovarian cancer', European Journal of Clinical Microbiology and Infectious Diseases, vol. 31, no. 9, pp. 2311-2317. https://doi.org/10.1007/s10096-012-1570-5

Viral and bacterial aetiologies of epithelial ovarian cancer. / Santhanam, Shanmughapriya; Vasanthi, N.; SenthilKumar, G.; Shanmughapriya, S.; Vinodhini, K.; Natarajaseenivasan, K.; Das, B. C.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 31, No. 9, 01.09.2012, p. 2311-2317.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Viral and bacterial aetiologies of epithelial ovarian cancer

AU - Santhanam, Shanmughapriya

AU - Vasanthi, N.

AU - SenthilKumar, G.

AU - Shanmughapriya, S.

AU - Vinodhini, K.

AU - Natarajaseenivasan, K.

AU - Das, B. C.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - We sought to analyse the presence of human papillomavirus (HPV), Chlamydia trachomatis and cytomegalovirus (CMV) infection in women with epithelial ovarian carcinomas. Polymerase chain reaction (PCR)-based detection of microbial infections was carried out. A total of 39 tissue samples were analysed with consensus and type-specific primers for HPV, primers specific for the cryptic plasmid of Chlamydia and primers for glycoprotein B of CMV. The samples analysed showed 40%, 80% and 50% positivity for HPV, Chlamydia and CMV infection, respectively, in cancerous ovarian tissues. The HPV type detected was HPV 6, with its genome integrated to the host genome in case of both invasive and borderline tumours and existed episomally in healthy controls. The patients with Chlamydia (odds ratio [OR] 32; 95% confidence interval [CI] 3.33, 307.65) and CMV infection (OR 8; 95% CI 0.888, 72.10) are at significantly higher risk of development of ovarian tumours. The present study validates the theory of chronic infections and inflammation in the pathogenesis of epithelial ovarian cancer. Further seroepidemiological studies and large fresh tissue sampling may represent the real prevalence of infections among ovarian carcinoma patients. This study is the first of its kind in detecting the bacterial and viral aetiologies in the development of ovarian carcinoma among Indian women.

AB - We sought to analyse the presence of human papillomavirus (HPV), Chlamydia trachomatis and cytomegalovirus (CMV) infection in women with epithelial ovarian carcinomas. Polymerase chain reaction (PCR)-based detection of microbial infections was carried out. A total of 39 tissue samples were analysed with consensus and type-specific primers for HPV, primers specific for the cryptic plasmid of Chlamydia and primers for glycoprotein B of CMV. The samples analysed showed 40%, 80% and 50% positivity for HPV, Chlamydia and CMV infection, respectively, in cancerous ovarian tissues. The HPV type detected was HPV 6, with its genome integrated to the host genome in case of both invasive and borderline tumours and existed episomally in healthy controls. The patients with Chlamydia (odds ratio [OR] 32; 95% confidence interval [CI] 3.33, 307.65) and CMV infection (OR 8; 95% CI 0.888, 72.10) are at significantly higher risk of development of ovarian tumours. The present study validates the theory of chronic infections and inflammation in the pathogenesis of epithelial ovarian cancer. Further seroepidemiological studies and large fresh tissue sampling may represent the real prevalence of infections among ovarian carcinoma patients. This study is the first of its kind in detecting the bacterial and viral aetiologies in the development of ovarian carcinoma among Indian women.

UR - http://www.scopus.com/inward/record.url?scp=84866419771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866419771&partnerID=8YFLogxK

U2 - 10.1007/s10096-012-1570-5

DO - 10.1007/s10096-012-1570-5

M3 - Article

VL - 31

SP - 2311

EP - 2317

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

SN - 0934-9723

IS - 9

ER -

Santhanam S, Vasanthi N, SenthilKumar G, Shanmughapriya S, Vinodhini K, Natarajaseenivasan K et al. Viral and bacterial aetiologies of epithelial ovarian cancer. European Journal of Clinical Microbiology and Infectious Diseases. 2012 Sep 1;31(9):2311-2317. https://doi.org/10.1007/s10096-012-1570-5