Viral clearance occurs very early during the natural resolution of hepatitis C virus infection in persons with haemophilia

M. Elaine Eyster, J. Sanders, J. J. Goedert

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    We studied spontaneous hepatitis C virus (HCV) RNA clearance in 12 haemophilic patients. In their earliest anti-HCV positive samples, HCV RNA was undetectable in eight patients (66%), positive by polymerase chain reaction (PCR) but negative by branched-DNA (bDNA) in three others, and quantifiable by bDNA (4839 IU/mL) in only one patient. In contrast, in earliest anti-HCV positive samples from eight matched controls who had persistent viremia, HCV RNA was quantifiable by bDNA in seven (P = 0.0008) and at higher levels (range 4644-678 515 IU/mL; median 43 532 IU/mL). From initial HCV infection, HCV RNA cleared in 7 months or less in four patients and in 1-2 years in six others. HCV persisted for 5 years before clearance in the absence of repeated exposure in one patient. We conclude that HCV clearance usually but not always occurs within 1-2 years after infection and is more likely in those with lower than in those with higher early viral loads.

    Original languageEnglish (US)
    Pages (from-to)75-80
    Number of pages6
    JournalHaemophilia
    Volume10
    Issue number1
    DOIs
    StatePublished - Jan 1 2004

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    Hemophilia A
    Virus Diseases
    Hepacivirus
    RNA
    DNA
    Viremia
    Viral Load
    Polymerase Chain Reaction
    Infection

    All Science Journal Classification (ASJC) codes

    • Hematology
    • Genetics(clinical)

    Cite this

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    abstract = "We studied spontaneous hepatitis C virus (HCV) RNA clearance in 12 haemophilic patients. In their earliest anti-HCV positive samples, HCV RNA was undetectable in eight patients (66{\%}), positive by polymerase chain reaction (PCR) but negative by branched-DNA (bDNA) in three others, and quantifiable by bDNA (4839 IU/mL) in only one patient. In contrast, in earliest anti-HCV positive samples from eight matched controls who had persistent viremia, HCV RNA was quantifiable by bDNA in seven (P = 0.0008) and at higher levels (range 4644-678 515 IU/mL; median 43 532 IU/mL). From initial HCV infection, HCV RNA cleared in 7 months or less in four patients and in 1-2 years in six others. HCV persisted for 5 years before clearance in the absence of repeated exposure in one patient. We conclude that HCV clearance usually but not always occurs within 1-2 years after infection and is more likely in those with lower than in those with higher early viral loads.",
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    Viral clearance occurs very early during the natural resolution of hepatitis C virus infection in persons with haemophilia. / Eyster, M. Elaine; Sanders, J.; Goedert, J. J.

    In: Haemophilia, Vol. 10, No. 1, 01.01.2004, p. 75-80.

    Research output: Contribution to journalArticle

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