Viral Genetic Diversity and Its Potential Contributions to the Development and Progression of Neonatal Herpes Simplex Virus (HSV) Disease

Lisa N. Akhtar, Moriah L. Szpara

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Neonatal infection by herpes simplex virus (HSV) 1 or 2 presents a devastating burden to new parents due to the unpredictability of severe clinical outcomes as well as the potential for lifelong viral reactivation. While just under half of neonatal HSV infections have mild clinical impacts akin to the skin lesions observed in adults, the other half of these infants experience viral spread throughout the body (disseminated infection) and/or the brain (central nervous system infection). Summary: Here we summarize current data on clinical diagnostic measures, antiviral therapy, and known aspects of human host biology that contribute to the distinct neonatal outcomes of HSV infection. Recent Findings: We then explore recent new data on how viral genetic diversity between infections may impact clinical outcomes. Further research will be critical to build upon these early findings and to provide statistical power to our ability to discern and/or predict the potential clinical course of a given neonatal infection.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalCurrent Clinical Microbiology Reports
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2019

Fingerprint

Virus Diseases
Simplexvirus
Infection
Central Nervous System Infections
Aptitude
Human Herpesvirus 2
Human Herpesvirus 1
Antiviral Agents
Parents
Skin
Neonatal herpes
Brain
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{842b7becfad74ce2997107601c278c9b,
title = "Viral Genetic Diversity and Its Potential Contributions to the Development and Progression of Neonatal Herpes Simplex Virus (HSV) Disease",
abstract = "Purpose of Review: Neonatal infection by herpes simplex virus (HSV) 1 or 2 presents a devastating burden to new parents due to the unpredictability of severe clinical outcomes as well as the potential for lifelong viral reactivation. While just under half of neonatal HSV infections have mild clinical impacts akin to the skin lesions observed in adults, the other half of these infants experience viral spread throughout the body (disseminated infection) and/or the brain (central nervous system infection). Summary: Here we summarize current data on clinical diagnostic measures, antiviral therapy, and known aspects of human host biology that contribute to the distinct neonatal outcomes of HSV infection. Recent Findings: We then explore recent new data on how viral genetic diversity between infections may impact clinical outcomes. Further research will be critical to build upon these early findings and to provide statistical power to our ability to discern and/or predict the potential clinical course of a given neonatal infection.",
author = "Akhtar, {Lisa N.} and Szpara, {Moriah L.}",
year = "2019",
month = "12",
day = "1",
doi = "10.1007/s40588-019-00131-6",
language = "English (US)",
volume = "6",
pages = "249--256",
journal = "Current Clinical Microbiology Reports",
issn = "2196-5471",
publisher = "Springer International Publishing AG",
number = "4",

}

TY - JOUR

T1 - Viral Genetic Diversity and Its Potential Contributions to the Development and Progression of Neonatal Herpes Simplex Virus (HSV) Disease

AU - Akhtar, Lisa N.

AU - Szpara, Moriah L.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Purpose of Review: Neonatal infection by herpes simplex virus (HSV) 1 or 2 presents a devastating burden to new parents due to the unpredictability of severe clinical outcomes as well as the potential for lifelong viral reactivation. While just under half of neonatal HSV infections have mild clinical impacts akin to the skin lesions observed in adults, the other half of these infants experience viral spread throughout the body (disseminated infection) and/or the brain (central nervous system infection). Summary: Here we summarize current data on clinical diagnostic measures, antiviral therapy, and known aspects of human host biology that contribute to the distinct neonatal outcomes of HSV infection. Recent Findings: We then explore recent new data on how viral genetic diversity between infections may impact clinical outcomes. Further research will be critical to build upon these early findings and to provide statistical power to our ability to discern and/or predict the potential clinical course of a given neonatal infection.

AB - Purpose of Review: Neonatal infection by herpes simplex virus (HSV) 1 or 2 presents a devastating burden to new parents due to the unpredictability of severe clinical outcomes as well as the potential for lifelong viral reactivation. While just under half of neonatal HSV infections have mild clinical impacts akin to the skin lesions observed in adults, the other half of these infants experience viral spread throughout the body (disseminated infection) and/or the brain (central nervous system infection). Summary: Here we summarize current data on clinical diagnostic measures, antiviral therapy, and known aspects of human host biology that contribute to the distinct neonatal outcomes of HSV infection. Recent Findings: We then explore recent new data on how viral genetic diversity between infections may impact clinical outcomes. Further research will be critical to build upon these early findings and to provide statistical power to our ability to discern and/or predict the potential clinical course of a given neonatal infection.

UR - http://www.scopus.com/inward/record.url?scp=85075455247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075455247&partnerID=8YFLogxK

U2 - 10.1007/s40588-019-00131-6

DO - 10.1007/s40588-019-00131-6

M3 - Review article

AN - SCOPUS:85075455247

VL - 6

SP - 249

EP - 256

JO - Current Clinical Microbiology Reports

JF - Current Clinical Microbiology Reports

SN - 2196-5471

IS - 4

ER -