Viral vectors for inducing CD8+ T cell responses

Mary E. Truckenmiller, Christopher C. Norbury

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

CD8+ T cells (TCD8+) can mediate protective immunity to intracellular pathogens and tumours. Viruses generate strong TCD8+ responses and, therefore, represent attractive vectors for generating vaccines aimed at producing TCD8+-mediated protective immunity. This review will examine the immunological properties of viruses that make them good candidates as vaccine vectors, as well as the manipulations of both vector and antigen that may be required to produce an effective vaccine. The areas addressed include virus infection of dendritic cells in vivo, stimulation of the innate immune response via intracellular and extracellular pattern recognition receptors, the effect of antigenic form on the pathways of antigen presentation and the requirement for elimination of viral genes that target various aspects of the innate and adaptive immune response.

Original languageEnglish (US)
Pages (from-to)861-868
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume4
Issue number6
DOIs
StatePublished - Jun 1 2004

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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