Virulence evolution in response to vaccination: The case of malaria

M. J. Mackinnon, S. Gandon, A. F. Read

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered.

Original languageEnglish (US)
Pages (from-to)C42-C52
JournalVaccine
Volume26
Issue numberSUPPL. 3
DOIs
StatePublished - Jul 18 2008

Fingerprint

malaria
Malaria
Virulence
Immunity
Parasites
Vaccination
virulence
Vaccines
vaccination
pathogens
immunity
vaccines
parasites
extracts
testing

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Mackinnon, M. J. ; Gandon, S. ; Read, A. F. / Virulence evolution in response to vaccination : The case of malaria. In: Vaccine. 2008 ; Vol. 26, No. SUPPL. 3. pp. C42-C52.
@article{46b2f10ea7024e09a0586d92296d1bce,
title = "Virulence evolution in response to vaccination: The case of malaria",
abstract = "One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered.",
author = "Mackinnon, {M. J.} and S. Gandon and Read, {A. F.}",
year = "2008",
month = "7",
day = "18",
doi = "10.1016/j.vaccine.2008.04.012",
language = "English (US)",
volume = "26",
pages = "C42--C52",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "SUPPL. 3",

}

Virulence evolution in response to vaccination : The case of malaria. / Mackinnon, M. J.; Gandon, S.; Read, A. F.

In: Vaccine, Vol. 26, No. SUPPL. 3, 18.07.2008, p. C42-C52.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Virulence evolution in response to vaccination

T2 - The case of malaria

AU - Mackinnon, M. J.

AU - Gandon, S.

AU - Read, A. F.

PY - 2008/7/18

Y1 - 2008/7/18

N2 - One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered.

AB - One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered.

UR - http://www.scopus.com/inward/record.url?scp=46049099988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46049099988&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2008.04.012

DO - 10.1016/j.vaccine.2008.04.012

M3 - Article

C2 - 18773536

AN - SCOPUS:46049099988

VL - 26

SP - C42-C52

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - SUPPL. 3

ER -