Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes

a CIBMTR contemporary longitudinal study

Maheen Z. Abidi, Parameswaran Hari, Min Chen, Soyoung Kim, Minoo Battiwala, Parastoo Bahrami Dahi, Miguel Angel Diaz, Robert Peter Gale, Siddhartha Ganguly, Usama Gergis, Jaime Green, Gerhard Hildebrandt, Joshua A. Hill, Krishna Komanduri, Hillard Lazarus, David Marks, Taiga Nishihori, Richard Olsson, Sachiko Seo, Celalettin Ustun & 7 others Jean Yared, Dwight Yin, John Wingard, Baldeep Wirk, Jeffrey Auletta, Caroline Lindemans, Marcie Riches

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. CNS viruses predominantly included human herpes virus 6 (HHV-6) (73%), followed by Epstein-Barr Virus (10%), cytomegalovirus (3%), varicella zoster virus (3%), herpes simplex virus (3%) and Adenovirus (3%). Median time of viral detection in CNS was 31 days after HCT; and viral detection was earlier in patients with CNS HHV-6. Concurrent viremia occurred in 52% of patients. Cord blood transplant recipients (CBT) accounted for the majority (53%) of patients with CNS-V. Myeloablative conditioning (65%), use of fludarabine (63%), or use of anti-thymocyte globulin (61%) were also predominant. Overall survival from the time of detection of CNS-V was 50% at 6 months and 30% at 5 years. Infections were the leading cause of death (32%). In summary, CBT recipients predominated in the population with CNS-V. Outcomes after CNS-V were poor with significant mortality seen in the first 6 months.

Original languageEnglish (US)
Pages (from-to)1354-1360
Number of pages7
JournalBone Marrow Transplantation
Volume54
Issue number8
DOIs
StatePublished - Aug 1 2019

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Hematopoietic Stem Cells
Longitudinal Studies
Cerebrospinal Fluid
Bone Marrow
Viruses
Transplants
Research
Central Nervous System
Fetal Blood
Human Herpesvirus 3
Antilymphocyte Serum
Viremia
Simplexvirus
Transplant Recipients
Cytomegalovirus
Human Herpesvirus 4
Adenoviridae
Cause of Death
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Abidi, Maheen Z. ; Hari, Parameswaran ; Chen, Min ; Kim, Soyoung ; Battiwala, Minoo ; Dahi, Parastoo Bahrami ; Diaz, Miguel Angel ; Gale, Robert Peter ; Ganguly, Siddhartha ; Gergis, Usama ; Green, Jaime ; Hildebrandt, Gerhard ; Hill, Joshua A. ; Komanduri, Krishna ; Lazarus, Hillard ; Marks, David ; Nishihori, Taiga ; Olsson, Richard ; Seo, Sachiko ; Ustun, Celalettin ; Yared, Jean ; Yin, Dwight ; Wingard, John ; Wirk, Baldeep ; Auletta, Jeffrey ; Lindemans, Caroline ; Riches, Marcie. / Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes : a CIBMTR contemporary longitudinal study. In: Bone Marrow Transplantation. 2019 ; Vol. 54, No. 8. pp. 1354-1360.
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title = "Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study",
abstract = "Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. CNS viruses predominantly included human herpes virus 6 (HHV-6) (73{\%}), followed by Epstein-Barr Virus (10{\%}), cytomegalovirus (3{\%}), varicella zoster virus (3{\%}), herpes simplex virus (3{\%}) and Adenovirus (3{\%}). Median time of viral detection in CNS was 31 days after HCT; and viral detection was earlier in patients with CNS HHV-6. Concurrent viremia occurred in 52{\%} of patients. Cord blood transplant recipients (CBT) accounted for the majority (53{\%}) of patients with CNS-V. Myeloablative conditioning (65{\%}), use of fludarabine (63{\%}), or use of anti-thymocyte globulin (61{\%}) were also predominant. Overall survival from the time of detection of CNS-V was 50{\%} at 6 months and 30{\%} at 5 years. Infections were the leading cause of death (32{\%}). In summary, CBT recipients predominated in the population with CNS-V. Outcomes after CNS-V were poor with significant mortality seen in the first 6 months.",
author = "Abidi, {Maheen Z.} and Parameswaran Hari and Min Chen and Soyoung Kim and Minoo Battiwala and Dahi, {Parastoo Bahrami} and Diaz, {Miguel Angel} and Gale, {Robert Peter} and Siddhartha Ganguly and Usama Gergis and Jaime Green and Gerhard Hildebrandt and Hill, {Joshua A.} and Krishna Komanduri and Hillard Lazarus and David Marks and Taiga Nishihori and Richard Olsson and Sachiko Seo and Celalettin Ustun and Jean Yared and Dwight Yin and John Wingard and Baldeep Wirk and Jeffrey Auletta and Caroline Lindemans and Marcie Riches",
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Abidi, MZ, Hari, P, Chen, M, Kim, S, Battiwala, M, Dahi, PB, Diaz, MA, Gale, RP, Ganguly, S, Gergis, U, Green, J, Hildebrandt, G, Hill, JA, Komanduri, K, Lazarus, H, Marks, D, Nishihori, T, Olsson, R, Seo, S, Ustun, C, Yared, J, Yin, D, Wingard, J, Wirk, B, Auletta, J, Lindemans, C & Riches, M 2019, 'Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study', Bone Marrow Transplantation, vol. 54, no. 8, pp. 1354-1360. https://doi.org/10.1038/s41409-019-0457-9

Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes : a CIBMTR contemporary longitudinal study. / Abidi, Maheen Z.; Hari, Parameswaran; Chen, Min; Kim, Soyoung; Battiwala, Minoo; Dahi, Parastoo Bahrami; Diaz, Miguel Angel; Gale, Robert Peter; Ganguly, Siddhartha; Gergis, Usama; Green, Jaime; Hildebrandt, Gerhard; Hill, Joshua A.; Komanduri, Krishna; Lazarus, Hillard; Marks, David; Nishihori, Taiga; Olsson, Richard; Seo, Sachiko; Ustun, Celalettin; Yared, Jean; Yin, Dwight; Wingard, John; Wirk, Baldeep; Auletta, Jeffrey; Lindemans, Caroline; Riches, Marcie.

In: Bone Marrow Transplantation, Vol. 54, No. 8, 01.08.2019, p. 1354-1360.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes

T2 - a CIBMTR contemporary longitudinal study

AU - Abidi, Maheen Z.

AU - Hari, Parameswaran

AU - Chen, Min

AU - Kim, Soyoung

AU - Battiwala, Minoo

AU - Dahi, Parastoo Bahrami

AU - Diaz, Miguel Angel

AU - Gale, Robert Peter

AU - Ganguly, Siddhartha

AU - Gergis, Usama

AU - Green, Jaime

AU - Hildebrandt, Gerhard

AU - Hill, Joshua A.

AU - Komanduri, Krishna

AU - Lazarus, Hillard

AU - Marks, David

AU - Nishihori, Taiga

AU - Olsson, Richard

AU - Seo, Sachiko

AU - Ustun, Celalettin

AU - Yared, Jean

AU - Yin, Dwight

AU - Wingard, John

AU - Wirk, Baldeep

AU - Auletta, Jeffrey

AU - Lindemans, Caroline

AU - Riches, Marcie

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. CNS viruses predominantly included human herpes virus 6 (HHV-6) (73%), followed by Epstein-Barr Virus (10%), cytomegalovirus (3%), varicella zoster virus (3%), herpes simplex virus (3%) and Adenovirus (3%). Median time of viral detection in CNS was 31 days after HCT; and viral detection was earlier in patients with CNS HHV-6. Concurrent viremia occurred in 52% of patients. Cord blood transplant recipients (CBT) accounted for the majority (53%) of patients with CNS-V. Myeloablative conditioning (65%), use of fludarabine (63%), or use of anti-thymocyte globulin (61%) were also predominant. Overall survival from the time of detection of CNS-V was 50% at 6 months and 30% at 5 years. Infections were the leading cause of death (32%). In summary, CBT recipients predominated in the population with CNS-V. Outcomes after CNS-V were poor with significant mortality seen in the first 6 months.

AB - Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. CNS viruses predominantly included human herpes virus 6 (HHV-6) (73%), followed by Epstein-Barr Virus (10%), cytomegalovirus (3%), varicella zoster virus (3%), herpes simplex virus (3%) and Adenovirus (3%). Median time of viral detection in CNS was 31 days after HCT; and viral detection was earlier in patients with CNS HHV-6. Concurrent viremia occurred in 52% of patients. Cord blood transplant recipients (CBT) accounted for the majority (53%) of patients with CNS-V. Myeloablative conditioning (65%), use of fludarabine (63%), or use of anti-thymocyte globulin (61%) were also predominant. Overall survival from the time of detection of CNS-V was 50% at 6 months and 30% at 5 years. Infections were the leading cause of death (32%). In summary, CBT recipients predominated in the population with CNS-V. Outcomes after CNS-V were poor with significant mortality seen in the first 6 months.

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DO - 10.1038/s41409-019-0457-9

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