Virus populations, mutation rates and frequencies

Justin S. Pita, Marilyn J. Roossinck

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Populations of plant viruses are genetically heterogeneous. This heterogeneity is often linked to mutation, the ultimate source of genetic variation and an uncontested player in plant virus evolution. This review gives basic key information indispensable to understanding mutation in plant viruses, from mutation sources, mutation detection means, to the role of mutation in shaping plant virus evolution in combination with various other evolutionary factors. From information drawn from the recent literature, we confirm or refute some generally held views and we reinstate several unanswered questions. It is clear that low genetic diversity characterizes some plant virus populations, irrespective of their life cycle or their nature (DNA or RNA). Mutation frequencies of plant DNA viruses can be as high as those of RNA viruses. This casts some doubt on a positive correlation between high mutation rates and adaptive evolution, and on the lack of proofreading for RNAdependent RNA polymerases. However, the lack of information on viral mutation rates still precludes a complete understanding of the link between mutation rates and population heterogeneity. Information about plant virus replication mode, generation time and generation size also is still crucially needed before a complete picture of virus evolution will emerge.

Original languageEnglish (US)
Title of host publicationPlant Virus Evolution
PublisherSpringer Berlin Heidelberg
Pages109-121
Number of pages13
ISBN (Print)9783540757627
DOIs
StatePublished - Dec 1 2008

Fingerprint

Plant Viruses
Mutation Rate
plant viruses
Viruses
mutation
viruses
Population
Mutation
Plant DNA
DNA Viruses
RNA Viruses
Population Characteristics
DNA-Directed RNA Polymerases
Virus Replication
Life Cycle Stages
DNA viruses
genetic variation
DNA-directed RNA polymerase
virus replication
RNA

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

Cite this

Pita, J. S., & Roossinck, M. J. (2008). Virus populations, mutation rates and frequencies. In Plant Virus Evolution (pp. 109-121). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-75763-4_6
Pita, Justin S. ; Roossinck, Marilyn J. / Virus populations, mutation rates and frequencies. Plant Virus Evolution. Springer Berlin Heidelberg, 2008. pp. 109-121
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Pita, JS & Roossinck, MJ 2008, Virus populations, mutation rates and frequencies. in Plant Virus Evolution. Springer Berlin Heidelberg, pp. 109-121. https://doi.org/10.1007/978-3-540-75763-4_6

Virus populations, mutation rates and frequencies. / Pita, Justin S.; Roossinck, Marilyn J.

Plant Virus Evolution. Springer Berlin Heidelberg, 2008. p. 109-121.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Pita JS, Roossinck MJ. Virus populations, mutation rates and frequencies. In Plant Virus Evolution. Springer Berlin Heidelberg. 2008. p. 109-121 https://doi.org/10.1007/978-3-540-75763-4_6