TY - JOUR
T1 - Viruses and antiviral immunity in Drosophila
AU - Xu, Jie
AU - Cherry, Sara
N1 - Funding Information:
We would like to thank Leah Sabin and members of the Cherry lab for helpful discussions. We apologize to the many individuals who we were unable to cite. This work was supported by Grants from the National Institutes of Health ( R01AI074951 , U54AI057168 and R01AI095500 ) to S.C. and a HHMI International Scholars award to J.X. S.C. is a recipient of the Burroughs Wellcome Investigators in the Pathogenesis of Infectious Disease Award .
PY - 2014/1
Y1 - 2014/1
N2 - Viral pathogens present many challenges to organisms, driving the evolution of a myriad of antiviral strategies to combat infections. A wide variety of viruses infect invertebrates, including both natural pathogens that are insect-restricted, and viruses that are transmitted to vertebrates. Studies using the powerful tools in the model organism Drosophila have expanded our understanding of antiviral defenses against diverse viruses. In this review, we will cover three major areas. First, we will describe the tools used to study viruses in Drosophila. Second, we will survey the major viruses that have been studied in Drosophila. And lastly, we will discuss the well-characterized mechanisms that are active against these diverse pathogens, focusing on non-RNAi mediated antiviral mechanisms. Antiviral RNAi is discussed in another paper in this issue.
AB - Viral pathogens present many challenges to organisms, driving the evolution of a myriad of antiviral strategies to combat infections. A wide variety of viruses infect invertebrates, including both natural pathogens that are insect-restricted, and viruses that are transmitted to vertebrates. Studies using the powerful tools in the model organism Drosophila have expanded our understanding of antiviral defenses against diverse viruses. In this review, we will cover three major areas. First, we will describe the tools used to study viruses in Drosophila. Second, we will survey the major viruses that have been studied in Drosophila. And lastly, we will discuss the well-characterized mechanisms that are active against these diverse pathogens, focusing on non-RNAi mediated antiviral mechanisms. Antiviral RNAi is discussed in another paper in this issue.
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U2 - 10.1016/j.dci.2013.05.002
DO - 10.1016/j.dci.2013.05.002
M3 - Article
C2 - 23680639
AN - SCOPUS:84886086043
SN - 0145-305X
VL - 42
SP - 67
EP - 84
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 1
ER -