Viscoelasticity of pediatric blood and its implications for the testing of a pulsatile pediatric blood pump

Jennifer A. Long, Akif Ündar, Keefe B. Manning, Steven Deutsch

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Red blood cell hematocrit, aggregation and deformability, and plasma protein concentration influence the viscosity and elasticity of whole blood. These parameters affect the flow properties, especially at low shear rates (< 50 s-1). In particular, we have previously shown that the viscoelasticity of fly id affects the inlet filling characteristics and regions of flow separation in small pulsatile blood pumps. Although the viscosity of pediatric blood has been thoroughly studied, its elasticity has not been previously measured. Here we present the viscosity and elasticity of pediatric blood against shear rate for hematocrits from 19-56, measured using an oscillatory rheometer. There is little effect of patient age on blood viscoelasticity. A statistical analysis showed that when compared at constant hematocrit, blood from adult and pediatric patients had similar viscoelastic properties. We present blood analog solutions, as a function of hematocrit, constructed on the basis of the pediatric measurements. Flow field results for viscoelastic analogs of 20, 40 and 60% hematocrit and a Newtonian analog will be compared in the initial, in vitro testing of the Penn State pediatric blood pump, to determine the importance of incorporating a viscoelastic analog into the desigh interaction.

Original languageEnglish (US)
Pages (from-to)563-566
Number of pages4
JournalASAIO Journal
Volume51
Issue number5
DOIs
StatePublished - Sep 1 2005

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Viscoelasticity of pediatric blood and its implications for the testing of a pulsatile pediatric blood pump'. Together they form a unique fingerprint.

  • Cite this