Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization

Homayoun Tabandeh, Harry W. Flynn, Ingrid Scott, Mary L. Lewis, Philip J. Rosenfeld, Francisco Rodriguez, Alvaro Rodriguez, Lawrence J. Singerman, Joyce Schiffman

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Abstract

Objective: To evaluate visual outcomes of untreated submacular choroidal neovascularization (CNV) in patients 50 years of age and older with high myopia. Design: Retrospective observational case series. Participants: Twenty-two eyes in 22 patients were studied. All were 50 years of age and older with myopia of 6.0 diopters (D) or greater or an axial length of 25.5 mm or greater. Patients had untreated CNV documented by clinical examination and fluorescein angiography at two medical centers between 1986 and 1997. Intervention: Demographic and clinical data were abstracted from patients' medical records. Main Outcome Measure: Visual acuity at 1 year after CNV diagnosis. Results: The study included 22 eyes of 22 patients (mean age, 63.1 years; mean refraction, -11.0 D). Baseline visual acuity (VA) in the study eye was 20/40 or greater in 2 (9%) patients, 20/50 to 20/150 in 9 (41%) patients, and 20/200 or less in 11 (50%) patients. Drusen were present in seven (32%) eyes, and lacquer cracks were noted in ten (45%) eyes. Mean refractive error was -7.0 D for patients with drusen and -12.5 D for patients without drusen. Choroidal neovascularization was less than 0.25 disc diameters (DD) in 11 (50%) eyes, 0.25 to 0.5 DD in 5 (23%) eyes, and greater than 0.5 DD in 6 (27%) eyes. Visual acuity in the study eye 1 year after CNV diagnosis was 20/40 or greater in 3 (14%) patients, 20/50 to 20/150 in 3 (14%) patients, and 20/200 or less in 16 (73%) eyes. The presence of drusen was significantly associated with older age and a lower degree of myopia but was not associated with size of the CNV or visual acuity outcome. Conclusion: When compared to patients younger than 50 years of age with high myopia and CNV reported in previous publications, the patients in the current series generally have poorer visual outcomes.

Original languageEnglish (US)
Pages (from-to)2063-2067
Number of pages5
JournalOphthalmology
Volume106
Issue number11
DOIs
StatePublished - Nov 1 1999

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Choroidal Neovascularization
Myopia
Visual Acuity
Lacquer
Refractive Errors
Fluorescein Angiography
Medical Records

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Tabandeh, Homayoun ; Flynn, Harry W. ; Scott, Ingrid ; Lewis, Mary L. ; Rosenfeld, Philip J. ; Rodriguez, Francisco ; Rodriguez, Alvaro ; Singerman, Lawrence J. ; Schiffman, Joyce. / Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization. In: Ophthalmology. 1999 ; Vol. 106, No. 11. pp. 2063-2067.
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title = "Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization",
abstract = "Objective: To evaluate visual outcomes of untreated submacular choroidal neovascularization (CNV) in patients 50 years of age and older with high myopia. Design: Retrospective observational case series. Participants: Twenty-two eyes in 22 patients were studied. All were 50 years of age and older with myopia of 6.0 diopters (D) or greater or an axial length of 25.5 mm or greater. Patients had untreated CNV documented by clinical examination and fluorescein angiography at two medical centers between 1986 and 1997. Intervention: Demographic and clinical data were abstracted from patients' medical records. Main Outcome Measure: Visual acuity at 1 year after CNV diagnosis. Results: The study included 22 eyes of 22 patients (mean age, 63.1 years; mean refraction, -11.0 D). Baseline visual acuity (VA) in the study eye was 20/40 or greater in 2 (9{\%}) patients, 20/50 to 20/150 in 9 (41{\%}) patients, and 20/200 or less in 11 (50{\%}) patients. Drusen were present in seven (32{\%}) eyes, and lacquer cracks were noted in ten (45{\%}) eyes. Mean refractive error was -7.0 D for patients with drusen and -12.5 D for patients without drusen. Choroidal neovascularization was less than 0.25 disc diameters (DD) in 11 (50{\%}) eyes, 0.25 to 0.5 DD in 5 (23{\%}) eyes, and greater than 0.5 DD in 6 (27{\%}) eyes. Visual acuity in the study eye 1 year after CNV diagnosis was 20/40 or greater in 3 (14{\%}) patients, 20/50 to 20/150 in 3 (14{\%}) patients, and 20/200 or less in 16 (73{\%}) eyes. The presence of drusen was significantly associated with older age and a lower degree of myopia but was not associated with size of the CNV or visual acuity outcome. Conclusion: When compared to patients younger than 50 years of age with high myopia and CNV reported in previous publications, the patients in the current series generally have poorer visual outcomes.",
author = "Homayoun Tabandeh and Flynn, {Harry W.} and Ingrid Scott and Lewis, {Mary L.} and Rosenfeld, {Philip J.} and Francisco Rodriguez and Alvaro Rodriguez and Singerman, {Lawrence J.} and Joyce Schiffman",
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Tabandeh, H, Flynn, HW, Scott, I, Lewis, ML, Rosenfeld, PJ, Rodriguez, F, Rodriguez, A, Singerman, LJ & Schiffman, J 1999, 'Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization', Ophthalmology, vol. 106, no. 11, pp. 2063-2067. https://doi.org/10.1016/S0161-6420(99)90484-0

Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization. / Tabandeh, Homayoun; Flynn, Harry W.; Scott, Ingrid; Lewis, Mary L.; Rosenfeld, Philip J.; Rodriguez, Francisco; Rodriguez, Alvaro; Singerman, Lawrence J.; Schiffman, Joyce.

In: Ophthalmology, Vol. 106, No. 11, 01.11.1999, p. 2063-2067.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization

AU - Tabandeh, Homayoun

AU - Flynn, Harry W.

AU - Scott, Ingrid

AU - Lewis, Mary L.

AU - Rosenfeld, Philip J.

AU - Rodriguez, Francisco

AU - Rodriguez, Alvaro

AU - Singerman, Lawrence J.

AU - Schiffman, Joyce

PY - 1999/11/1

Y1 - 1999/11/1

N2 - Objective: To evaluate visual outcomes of untreated submacular choroidal neovascularization (CNV) in patients 50 years of age and older with high myopia. Design: Retrospective observational case series. Participants: Twenty-two eyes in 22 patients were studied. All were 50 years of age and older with myopia of 6.0 diopters (D) or greater or an axial length of 25.5 mm or greater. Patients had untreated CNV documented by clinical examination and fluorescein angiography at two medical centers between 1986 and 1997. Intervention: Demographic and clinical data were abstracted from patients' medical records. Main Outcome Measure: Visual acuity at 1 year after CNV diagnosis. Results: The study included 22 eyes of 22 patients (mean age, 63.1 years; mean refraction, -11.0 D). Baseline visual acuity (VA) in the study eye was 20/40 or greater in 2 (9%) patients, 20/50 to 20/150 in 9 (41%) patients, and 20/200 or less in 11 (50%) patients. Drusen were present in seven (32%) eyes, and lacquer cracks were noted in ten (45%) eyes. Mean refractive error was -7.0 D for patients with drusen and -12.5 D for patients without drusen. Choroidal neovascularization was less than 0.25 disc diameters (DD) in 11 (50%) eyes, 0.25 to 0.5 DD in 5 (23%) eyes, and greater than 0.5 DD in 6 (27%) eyes. Visual acuity in the study eye 1 year after CNV diagnosis was 20/40 or greater in 3 (14%) patients, 20/50 to 20/150 in 3 (14%) patients, and 20/200 or less in 16 (73%) eyes. The presence of drusen was significantly associated with older age and a lower degree of myopia but was not associated with size of the CNV or visual acuity outcome. Conclusion: When compared to patients younger than 50 years of age with high myopia and CNV reported in previous publications, the patients in the current series generally have poorer visual outcomes.

AB - Objective: To evaluate visual outcomes of untreated submacular choroidal neovascularization (CNV) in patients 50 years of age and older with high myopia. Design: Retrospective observational case series. Participants: Twenty-two eyes in 22 patients were studied. All were 50 years of age and older with myopia of 6.0 diopters (D) or greater or an axial length of 25.5 mm or greater. Patients had untreated CNV documented by clinical examination and fluorescein angiography at two medical centers between 1986 and 1997. Intervention: Demographic and clinical data were abstracted from patients' medical records. Main Outcome Measure: Visual acuity at 1 year after CNV diagnosis. Results: The study included 22 eyes of 22 patients (mean age, 63.1 years; mean refraction, -11.0 D). Baseline visual acuity (VA) in the study eye was 20/40 or greater in 2 (9%) patients, 20/50 to 20/150 in 9 (41%) patients, and 20/200 or less in 11 (50%) patients. Drusen were present in seven (32%) eyes, and lacquer cracks were noted in ten (45%) eyes. Mean refractive error was -7.0 D for patients with drusen and -12.5 D for patients without drusen. Choroidal neovascularization was less than 0.25 disc diameters (DD) in 11 (50%) eyes, 0.25 to 0.5 DD in 5 (23%) eyes, and greater than 0.5 DD in 6 (27%) eyes. Visual acuity in the study eye 1 year after CNV diagnosis was 20/40 or greater in 3 (14%) patients, 20/50 to 20/150 in 3 (14%) patients, and 20/200 or less in 16 (73%) eyes. The presence of drusen was significantly associated with older age and a lower degree of myopia but was not associated with size of the CNV or visual acuity outcome. Conclusion: When compared to patients younger than 50 years of age with high myopia and CNV reported in previous publications, the patients in the current series generally have poorer visual outcomes.

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