Visual working memory deficits in patients with Parkinson's disease are due to both reduced storage capacity and impaired ability to filter out irrelevant information

Eun Young Lee, Nelson Cowan, Edward K. Vogel, Terry Rolan, Fernando Valle-Inclán, Steven A. Hackley

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Given that Parkinson's disease broadly affects frontostriatal circuitry, it is not surprising that the disorder is associated with a reduction of working memory. We tested whether this reduction is due to diminished storage capacity or impaired ability to exclude task-irrelevant items. Twenty-one medication-withdrawn patients and 28 age-matched control subjects performed a visuospatial memory task while their electroencephalograms were recorded. The task required them to remember the orientations of red rectangles within the half of the screen that was cued while ignoring all green rectangles. Behavioural and electroencephalogram measures indicated that patients with Parkinson's disease were impaired at filtering out distracters, and that they were able to hold fewer items in memory than control subjects. The results support recent suggestions that the basal ganglia help control access to working memory.

Original languageEnglish (US)
Pages (from-to)2677-2689
Number of pages13
JournalBrain
Volume133
Issue number9
DOIs
StatePublished - Sep 2010

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Aptitude
Memory Disorders
Short-Term Memory
Parkinson Disease
Electroencephalography
Basal Ganglia

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Lee, Eun Young ; Cowan, Nelson ; Vogel, Edward K. ; Rolan, Terry ; Valle-Inclán, Fernando ; Hackley, Steven A. / Visual working memory deficits in patients with Parkinson's disease are due to both reduced storage capacity and impaired ability to filter out irrelevant information. In: Brain. 2010 ; Vol. 133, No. 9. pp. 2677-2689.
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Visual working memory deficits in patients with Parkinson's disease are due to both reduced storage capacity and impaired ability to filter out irrelevant information. / Lee, Eun Young; Cowan, Nelson; Vogel, Edward K.; Rolan, Terry; Valle-Inclán, Fernando; Hackley, Steven A.

In: Brain, Vol. 133, No. 9, 09.2010, p. 2677-2689.

Research output: Contribution to journalArticle

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