Vitamin A and Retinoic Acid in the Regulation of B-Cell Development and Antibody Production

A. Catharine Ross, Qiuyan Chen, Yifan Ma

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Signaling by vitamin A through its active metabolite retinoic acid (RA) is critical for the normal development and functions of the hematopoietic and immune systems. B cells, as both factories for antibody production and part of the immune regulatory system, are critical to a successful vaccination response. RA is a factor in the development and competence of mature B cells, in B cell proliferation, and in the regulation of transcription factors associated with B cell differentiation, class switch recombination, and the generation of antibody-secreting plasma cells. Emerging evidence suggests that RA can function alone and in combination with other immune system stimuli to augment the formation of germinal centers, leading to increased primary and secondary antibody responses. Taken together, RA could be a useful component in vaccine strategies and/or for immunotherapy.

Original languageEnglish (US)
Pages (from-to)103-126
Number of pages24
JournalVitamins and Hormones
Volume86
DOIs
StatePublished - Mar 21 2011

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology

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