Vitamin A and the immune system

A. C. Ross, K. H. Restori

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Vitamin A is required in the diet of all vertebrates, and is metabolized intracellularly to retinoic acid (RA), which is well known as a regulator of cell proliferation and differentiation. RA activates nuclear retinoid receptors and regulates a wide variety of genes. This chapter first discusses vitamin A nutrition and metabolism, and then how inflammation affects the metabolism of vitamin A compounds. Clinically, RA and several analogs are used in the treatment of skin disorders. Vitamin A deficiency is a risk factor for infectious disease. This chapter discusses the role of vitamin A in the immune system, especially in the regulation of T cell differentiation and in innate immunity.

Original languageEnglish (US)
Title of host publicationDiet, Immunity and Inflammation
PublisherElsevier Ltd
Pages221-243
Number of pages23
ISBN (Print)9780857090379
DOIs
StatePublished - Sep 2013

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Ross, A. C., & Restori, K. H. (2013). Vitamin A and the immune system. In Diet, Immunity and Inflammation (pp. 221-243). Elsevier Ltd. https://doi.org/10.1533/9780857095749.2.221