TY - JOUR
T1 - Vitamin A deficiency exacerbates murine lyme arthritis
AU - Cantorna, Margherita T.
AU - Hayes, Colleen E.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - Vitamin A deficiency predisposes the host for a strong inflammatory response, suggesting that it may foster susceptibility to diseases, such as Lyme arthritis, in which activated macrophage and inflammatory cytokine production are pathogenic. Infected mice had a rapid serum retinol decline that correlated with the onset of arthritis. The mice with the least retinol developed acute arthritis earlier and more severely than those with the highest retinol. Earlier and stronger interleukin (IL)-12, interferon-γ (IFN)-γ, and tumor necrosis factor responses were found in Borrelia burgdorferi-infected, vitamin A-deficient mice compared with controls. The spirochetes induced IFN-γ secretion from unprimed cells, and retinoid addition in vitro inhibited IFN-γ synthesis. Vitamin A deficiency may exacerbate acute Lyme arthritis by enhancing an acute arthritogenic inflammatory response initiated by spirochete-driven IFN-γ secretion. Conversely, vitamin A may lessen acute Lyme arthritis pathology by blocking IFN-γ and IL-12 synthesis.
AB - Vitamin A deficiency predisposes the host for a strong inflammatory response, suggesting that it may foster susceptibility to diseases, such as Lyme arthritis, in which activated macrophage and inflammatory cytokine production are pathogenic. Infected mice had a rapid serum retinol decline that correlated with the onset of arthritis. The mice with the least retinol developed acute arthritis earlier and more severely than those with the highest retinol. Earlier and stronger interleukin (IL)-12, interferon-γ (IFN)-γ, and tumor necrosis factor responses were found in Borrelia burgdorferi-infected, vitamin A-deficient mice compared with controls. The spirochetes induced IFN-γ secretion from unprimed cells, and retinoid addition in vitro inhibited IFN-γ synthesis. Vitamin A deficiency may exacerbate acute Lyme arthritis by enhancing an acute arthritogenic inflammatory response initiated by spirochete-driven IFN-γ secretion. Conversely, vitamin A may lessen acute Lyme arthritis pathology by blocking IFN-γ and IL-12 synthesis.
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U2 - 10.1093/infdis/174.4.747
DO - 10.1093/infdis/174.4.747
M3 - Article
C2 - 8843212
AN - SCOPUS:0029792626
VL - 174
SP - 747
EP - 751
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -