Abstract
To determine the ability of young rats to produce antibody against pneumococcal polysaccharide (SSS-III), weanling rats were fed a semipurified diet containing no retinol (A-) or 4 μg retinol/g diet (A+). Splenic antibody response specific to SSS-III was 17% (p ≤ 0.05) of control for A- Sprague-Dawley rats; similarly, the response of retinol-depleted Lewis rats was 22% (p ≤ 0.05) of pair-fed controls. No kinetic differences were observed in the antibody response between A- and control Lewis rats. Retinol depletion more markedly reduced the antibody response of male than female rats despite equally low tissue retinol concentrations. For both strains, retinol repletion near the time of immunization normalized antibody production. When male Lewis rats were fed the A- diet longer, the antibody response of A- rats was only 3% of pair-fed controls; repletion again normalized antibody production. Thus, retinol supplementation near the time of immunization can restore the immune response in previously compromised A- rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 501-510 |
| Number of pages | 10 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 49 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1989 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Nutrition and Dietetics
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Vitamin A depletion and repletion : Effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III). / Pasatiempo, A. M.G.; Bowman, T. A.; Taylor, C. E.; Ross, A. Catharine.
In: American Journal of Clinical Nutrition, Vol. 49, No. 3, 01.01.1989, p. 501-510.Research output: Contribution to journal › Article
TY - JOUR
T1 - Vitamin A depletion and repletion
T2 - Effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III)
AU - Pasatiempo, A. M.G.
AU - Bowman, T. A.
AU - Taylor, C. E.
AU - Ross, A. Catharine
PY - 1989/1/1
Y1 - 1989/1/1
N2 - To determine the ability of young rats to produce antibody against pneumococcal polysaccharide (SSS-III), weanling rats were fed a semipurified diet containing no retinol (A-) or 4 μg retinol/g diet (A+). Splenic antibody response specific to SSS-III was 17% (p ≤ 0.05) of control for A- Sprague-Dawley rats; similarly, the response of retinol-depleted Lewis rats was 22% (p ≤ 0.05) of pair-fed controls. No kinetic differences were observed in the antibody response between A- and control Lewis rats. Retinol depletion more markedly reduced the antibody response of male than female rats despite equally low tissue retinol concentrations. For both strains, retinol repletion near the time of immunization normalized antibody production. When male Lewis rats were fed the A- diet longer, the antibody response of A- rats was only 3% of pair-fed controls; repletion again normalized antibody production. Thus, retinol supplementation near the time of immunization can restore the immune response in previously compromised A- rats.
AB - To determine the ability of young rats to produce antibody against pneumococcal polysaccharide (SSS-III), weanling rats were fed a semipurified diet containing no retinol (A-) or 4 μg retinol/g diet (A+). Splenic antibody response specific to SSS-III was 17% (p ≤ 0.05) of control for A- Sprague-Dawley rats; similarly, the response of retinol-depleted Lewis rats was 22% (p ≤ 0.05) of pair-fed controls. No kinetic differences were observed in the antibody response between A- and control Lewis rats. Retinol depletion more markedly reduced the antibody response of male than female rats despite equally low tissue retinol concentrations. For both strains, retinol repletion near the time of immunization normalized antibody production. When male Lewis rats were fed the A- diet longer, the antibody response of A- rats was only 3% of pair-fed controls; repletion again normalized antibody production. Thus, retinol supplementation near the time of immunization can restore the immune response in previously compromised A- rats.
UR - http://www.scopus.com/inward/record.url?scp=0024515247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024515247&partnerID=8YFLogxK
U2 - 10.1093/ajcn/49.3.501
DO - 10.1093/ajcn/49.3.501
M3 - Article
C2 - 2784283
AN - SCOPUS:0024515247
VL - 49
SP - 501
EP - 510
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 3
ER -