Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats

Ting Li, Agostino Molteni, Predrag Latkovich, William Castellani, Richard C. Baybutt

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We showed previously that vitamin A deficiency per se causes emphysema. Benzo(a)pyrene, a constituent in cigarette smoke, induces vitamin A depletion when administered to rats; therefore, we tested the hypothesis that cigarette smoke induces vitamin A depletion, which is associated with the development of emphysema. Male weanling rats were fed a purified AIN-93G diet and divided into two groups. The experimental group was exposed to cigarette smoke from 20 nonfiltered commercial cigarettes/d for 5 d/wk, whereas the control group was exposed to air. After 6 wk, tissues were collected for histological and biochemical analyses. Retinol levels were measured in serum, lung and liver. The trachea, lung and liver were examined for histological changes. Vitamin A levels decreased significantly in serum, lung and liver of smoke-treated rats. Histological examination revealed the presence of interstitial pneumonitis along with severe emphysema. There was a significant inverse relationship between vitamin A concentration in the lung and the severity of emphysema (r = -0.69 and P < 0.03). Detachment or hyperplasia (and metaplasia) of the tracheal epithelium and liver vacuole formation also were evident in the smoke-treated rats. The results of this research indicate that exposure to cigarette smoke induces vitamin A depletion in rats, which is associated with the development of emphysema.

Original languageEnglish (US)
Pages (from-to)2629-2634
Number of pages6
JournalJournal of Nutrition
Volume133
Issue number8
StatePublished - Aug 1 2003

Fingerprint

cigarettes
Emphysema
smoke
Vitamin A
Smoke
Tobacco Products
vitamin A
rats
lungs
Lung
liver
Liver
Vitamin A Deficiency
metaplasia
trachea (vertebrates)
vitamin A deficiency
Benzo(a)pyrene
Interstitial Lung Diseases
Metaplasia
Vacuoles

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Li, T., Molteni, A., Latkovich, P., Castellani, W., & Baybutt, R. C. (2003). Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats. Journal of Nutrition, 133(8), 2629-2634.
Li, Ting ; Molteni, Agostino ; Latkovich, Predrag ; Castellani, William ; Baybutt, Richard C. / Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats. In: Journal of Nutrition. 2003 ; Vol. 133, No. 8. pp. 2629-2634.
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Li, T, Molteni, A, Latkovich, P, Castellani, W & Baybutt, RC 2003, 'Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats', Journal of Nutrition, vol. 133, no. 8, pp. 2629-2634.

Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats. / Li, Ting; Molteni, Agostino; Latkovich, Predrag; Castellani, William; Baybutt, Richard C.

In: Journal of Nutrition, Vol. 133, No. 8, 01.08.2003, p. 2629-2634.

Research output: Contribution to journalArticle

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Li T, Molteni A, Latkovich P, Castellani W, Baybutt RC. Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats. Journal of Nutrition. 2003 Aug 1;133(8):2629-2634.