Vitamin a intake affects the contribution of chylomicrons vs. Retinol-binding protein to milk vitamin A in lactating rats

Michael Henry Green, Joanne Balmer Green, Sylvie A. Akohoue, Sean K. Kelley

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

To investigate the influence of vitamin A intake on the contribution of chylomicrons vs. holo retinol-binding protein to milk vitamin A, female rats were fed diets containing either 10 (n = 6) or 50 μmol vitamin A/kg body (n = 4) during pregnancy and through d 13 of lactation. [3H]Vitamin A was incorporated into each diet beginning on d 6 of lactation. Vitamin A concentrations on d 13 were significantly higher in dam liver (x 3), pup liver (x 2.6), milk (x 2.5) and mammary tissue (x 1.3) in rats consuming the higher level of vitamin A. In both groups, vitamin A specific activities in plasma and milk reached apparent plateaus by 2.33 d after addition of [3H]vitamin A to the diets. Vitamin A specific activity in milk was higher than in plasma at all times in both groups. The estimated minimum contribution of chylomicrons to milk vitamin A was 32 ± 3% in rats fed the lower level of vitamin A vs. 52 ± 10% at the higher level (P = 0.014). We concluded that dietary vitamin A, like triglycerides, may be directed to mammary tissue during lactation for preferential secretion into milk; thus, increasing vitamin A intakes will increase the contribution of dietary vitamin A to milk. In contrast to milk, mammary tissue vitamin A turns over very slowly.

Original languageEnglish (US)
Pages (from-to)1279-1282
Number of pages4
JournalJournal of Nutrition
Volume131
Issue number4
StatePublished - Apr 18 2001

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Chylomicrons
Retinol-Binding Proteins
Vitamin A
Vitamins
Milk
Lactation
Breast
Diet
Liver

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Green, Michael Henry ; Green, Joanne Balmer ; Akohoue, Sylvie A. ; Kelley, Sean K. / Vitamin a intake affects the contribution of chylomicrons vs. Retinol-binding protein to milk vitamin A in lactating rats. In: Journal of Nutrition. 2001 ; Vol. 131, No. 4. pp. 1279-1282.
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abstract = "To investigate the influence of vitamin A intake on the contribution of chylomicrons vs. holo retinol-binding protein to milk vitamin A, female rats were fed diets containing either 10 (n = 6) or 50 μmol vitamin A/kg body (n = 4) during pregnancy and through d 13 of lactation. [3H]Vitamin A was incorporated into each diet beginning on d 6 of lactation. Vitamin A concentrations on d 13 were significantly higher in dam liver (x 3), pup liver (x 2.6), milk (x 2.5) and mammary tissue (x 1.3) in rats consuming the higher level of vitamin A. In both groups, vitamin A specific activities in plasma and milk reached apparent plateaus by 2.33 d after addition of [3H]vitamin A to the diets. Vitamin A specific activity in milk was higher than in plasma at all times in both groups. The estimated minimum contribution of chylomicrons to milk vitamin A was 32 ± 3{\%} in rats fed the lower level of vitamin A vs. 52 ± 10{\%} at the higher level (P = 0.014). We concluded that dietary vitamin A, like triglycerides, may be directed to mammary tissue during lactation for preferential secretion into milk; thus, increasing vitamin A intakes will increase the contribution of dietary vitamin A to milk. In contrast to milk, mammary tissue vitamin A turns over very slowly.",
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Vitamin a intake affects the contribution of chylomicrons vs. Retinol-binding protein to milk vitamin A in lactating rats. / Green, Michael Henry; Green, Joanne Balmer; Akohoue, Sylvie A.; Kelley, Sean K.

In: Journal of Nutrition, Vol. 131, No. 4, 18.04.2001, p. 1279-1282.

Research output: Contribution to journalArticle

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