Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition

Mark Lucock, Rohith Thota, Manohar Garg, Charlotte Martin, Patrice Jones, John Furst, Zoe Yates, Nina G. Jablonski, George Chaplin, Martin Veysey, Jessie M. Sutherland, Emma Beckett

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D3 Levels; (2) to explore whether folate-related gene variants that influence/alter DNA-thymidylate and methyl group biosynthesis modify any associations detected in objective 1; and (3) to consider whether these processes might influence reproductive success consistent with the “folate-vitamin D-UV hypothesis of skin pigmentation” evolutionary model. Methods: A large (n = 649) Australian cross-sectional study population was examined. Polymerase chain reaction (PCR)/Restriction fragment length polymorphism (RFLP) analysis was used to genotype C677T-MTHFR, C1420T-SHMT, T401C-MTHFD and 2R > 3R-TS. RCF was measured by chemiluminescent immunoassay and vitamin D2 and D3 by HPLC. Results: RCF and photosynthesized vitamin D3, but not RCF and dietary vitamin D2, exhibit a significant reciprocal association in spring and summer. Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer. Effects are seasonal, and do not occur over the whole year. Conclusions: Findings are consistent with what might be required for the “folate-vitamin D-UV hypothesis of skin pigmentation” model. It suggests genetic influence in provision of one-carbon units by 5,10-methylene-H4folate, may be an important factor in what appears to be a clear seasonal relationship between vitamin D3 and folate status.

Original languageEnglish (US)
Article numbere23166
JournalAmerican Journal of Human Biology
Volume30
Issue number5
DOIs
StatePublished - Sep 1 2018

Fingerprint

vitamin
vitamin D
Folic Acid
Vitamin D
folic acid
disposition
seasonality
cholecalciferol
Cholecalciferol
cross-sectional study
ergocalciferol
Skin Pigmentation
Ergocalciferols
skin
pigmentation
Group
gene
immunoassay
cells
summer

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Ecology, Evolution, Behavior and Systematics
  • Anthropology
  • Genetics

Cite this

Lucock, Mark ; Thota, Rohith ; Garg, Manohar ; Martin, Charlotte ; Jones, Patrice ; Furst, John ; Yates, Zoe ; Jablonski, Nina G. ; Chaplin, George ; Veysey, Martin ; Sutherland, Jessie M. ; Beckett, Emma. / Vitamin D and folate : A reciprocal environmental association based on seasonality and genetic disposition. In: American Journal of Human Biology. 2018 ; Vol. 30, No. 5.
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title = "Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition",
abstract = "Objectives: The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D3 Levels; (2) to explore whether folate-related gene variants that influence/alter DNA-thymidylate and methyl group biosynthesis modify any associations detected in objective 1; and (3) to consider whether these processes might influence reproductive success consistent with the “folate-vitamin D-UV hypothesis of skin pigmentation” evolutionary model. Methods: A large (n = 649) Australian cross-sectional study population was examined. Polymerase chain reaction (PCR)/Restriction fragment length polymorphism (RFLP) analysis was used to genotype C677T-MTHFR, C1420T-SHMT, T401C-MTHFD and 2R > 3R-TS. RCF was measured by chemiluminescent immunoassay and vitamin D2 and D3 by HPLC. Results: RCF and photosynthesized vitamin D3, but not RCF and dietary vitamin D2, exhibit a significant reciprocal association in spring and summer. Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer. Effects are seasonal, and do not occur over the whole year. Conclusions: Findings are consistent with what might be required for the “folate-vitamin D-UV hypothesis of skin pigmentation” model. It suggests genetic influence in provision of one-carbon units by 5,10-methylene-H4folate, may be an important factor in what appears to be a clear seasonal relationship between vitamin D3 and folate status.",
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Lucock, M, Thota, R, Garg, M, Martin, C, Jones, P, Furst, J, Yates, Z, Jablonski, NG, Chaplin, G, Veysey, M, Sutherland, JM & Beckett, E 2018, 'Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition', American Journal of Human Biology, vol. 30, no. 5, e23166. https://doi.org/10.1002/ajhb.23166

Vitamin D and folate : A reciprocal environmental association based on seasonality and genetic disposition. / Lucock, Mark; Thota, Rohith; Garg, Manohar; Martin, Charlotte; Jones, Patrice; Furst, John; Yates, Zoe; Jablonski, Nina G.; Chaplin, George; Veysey, Martin; Sutherland, Jessie M.; Beckett, Emma.

In: American Journal of Human Biology, Vol. 30, No. 5, e23166, 01.09.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin D and folate

T2 - A reciprocal environmental association based on seasonality and genetic disposition

AU - Lucock, Mark

AU - Thota, Rohith

AU - Garg, Manohar

AU - Martin, Charlotte

AU - Jones, Patrice

AU - Furst, John

AU - Yates, Zoe

AU - Jablonski, Nina G.

AU - Chaplin, George

AU - Veysey, Martin

AU - Sutherland, Jessie M.

AU - Beckett, Emma

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objectives: The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D3 Levels; (2) to explore whether folate-related gene variants that influence/alter DNA-thymidylate and methyl group biosynthesis modify any associations detected in objective 1; and (3) to consider whether these processes might influence reproductive success consistent with the “folate-vitamin D-UV hypothesis of skin pigmentation” evolutionary model. Methods: A large (n = 649) Australian cross-sectional study population was examined. Polymerase chain reaction (PCR)/Restriction fragment length polymorphism (RFLP) analysis was used to genotype C677T-MTHFR, C1420T-SHMT, T401C-MTHFD and 2R > 3R-TS. RCF was measured by chemiluminescent immunoassay and vitamin D2 and D3 by HPLC. Results: RCF and photosynthesized vitamin D3, but not RCF and dietary vitamin D2, exhibit a significant reciprocal association in spring and summer. Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer. Effects are seasonal, and do not occur over the whole year. Conclusions: Findings are consistent with what might be required for the “folate-vitamin D-UV hypothesis of skin pigmentation” model. It suggests genetic influence in provision of one-carbon units by 5,10-methylene-H4folate, may be an important factor in what appears to be a clear seasonal relationship between vitamin D3 and folate status.

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