Vitamin D and host resistance to infection? Putting the cart in front of the horse

Danny Bruce, Jot Hui Ooi, Sanhong Yu, Margherita T. Cantorna

Research output: Contribution to journalShort survey

49 Citations (Scopus)

Abstract

Vitamin D is being touted as an anti-infective agent and it has even been suggested that vitamin D supplementation could be effective against the H1N1 influenza virus. The claims are largely based on the ability of vitamin D to induce antibacterial peptides and evidence that the immune system produces active vitamin D (1,25(OH)2D3) in situ. While there are many examples of immune production of 1,25(OH)2D3 in vitro, there is little in vivo evidence. In addition, it is not clear what role immune production of 1,25(OH)2D3 has on the course of disease. Vitamin D and 1,25(OH)2D3 inhibit T helper type 1 (Th1)/ Th17-mediated immune responses and autoimmune diseases by acting on the innate and acquired immune system to inhibit the function of Th1 and Th17 cells. Th1 and Th17 cells are important in host resistance to many infections including tuberculosis (TB) caused by Mycobacterium tuberculosis. Paradoxically the innate immune system is induced to produce antibacterial peptides that are effective against TB in vitro. Data from several models of infection have so far not supported a role for vitamin D in affecting the course of disease. There is also very little evidence that vitamin D affects the course of human TB infection. Experiments have not been done in cells, mice or humans to evaluate the effect of vitamin D on influenza virus. At this time it would be premature to claim that vitamin D has an effect on TB, influenza or any other infection.

Original languageEnglish (US)
Pages (from-to)921-927
Number of pages7
JournalExperimental Biology and Medicine
Volume235
Issue number8
DOIs
StatePublished - Aug 1 2010

Fingerprint

Vitamin D
Horses
Infection
Immune system
Tuberculosis
Th17 Cells
Immune System
Th1 Cells
Orthomyxoviridae
Viruses
H1N1 Subtype Influenza A Virus
Peptides
Immune System Diseases
Anti-Infective Agents
Mycobacterium tuberculosis
Human Influenza
Autoimmune Diseases

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

@article{a4f495c1b1904d95b34b5d54e4320d6b,
title = "Vitamin D and host resistance to infection? Putting the cart in front of the horse",
abstract = "Vitamin D is being touted as an anti-infective agent and it has even been suggested that vitamin D supplementation could be effective against the H1N1 influenza virus. The claims are largely based on the ability of vitamin D to induce antibacterial peptides and evidence that the immune system produces active vitamin D (1,25(OH)2D3) in situ. While there are many examples of immune production of 1,25(OH)2D3 in vitro, there is little in vivo evidence. In addition, it is not clear what role immune production of 1,25(OH)2D3 has on the course of disease. Vitamin D and 1,25(OH)2D3 inhibit T helper type 1 (Th1)/ Th17-mediated immune responses and autoimmune diseases by acting on the innate and acquired immune system to inhibit the function of Th1 and Th17 cells. Th1 and Th17 cells are important in host resistance to many infections including tuberculosis (TB) caused by Mycobacterium tuberculosis. Paradoxically the innate immune system is induced to produce antibacterial peptides that are effective against TB in vitro. Data from several models of infection have so far not supported a role for vitamin D in affecting the course of disease. There is also very little evidence that vitamin D affects the course of human TB infection. Experiments have not been done in cells, mice or humans to evaluate the effect of vitamin D on influenza virus. At this time it would be premature to claim that vitamin D has an effect on TB, influenza or any other infection.",
author = "Danny Bruce and Ooi, {Jot Hui} and Sanhong Yu and Cantorna, {Margherita T.}",
year = "2010",
month = "8",
day = "1",
doi = "10.1258/ebm.2010.010061",
language = "English (US)",
volume = "235",
pages = "921--927",
journal = "Experimental Biology and Medicine",
issn = "1535-3702",
publisher = "SAGE Publications Ltd",
number = "8",

}

Vitamin D and host resistance to infection? Putting the cart in front of the horse. / Bruce, Danny; Ooi, Jot Hui; Yu, Sanhong; Cantorna, Margherita T.

In: Experimental Biology and Medicine, Vol. 235, No. 8, 01.08.2010, p. 921-927.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Vitamin D and host resistance to infection? Putting the cart in front of the horse

AU - Bruce, Danny

AU - Ooi, Jot Hui

AU - Yu, Sanhong

AU - Cantorna, Margherita T.

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Vitamin D is being touted as an anti-infective agent and it has even been suggested that vitamin D supplementation could be effective against the H1N1 influenza virus. The claims are largely based on the ability of vitamin D to induce antibacterial peptides and evidence that the immune system produces active vitamin D (1,25(OH)2D3) in situ. While there are many examples of immune production of 1,25(OH)2D3 in vitro, there is little in vivo evidence. In addition, it is not clear what role immune production of 1,25(OH)2D3 has on the course of disease. Vitamin D and 1,25(OH)2D3 inhibit T helper type 1 (Th1)/ Th17-mediated immune responses and autoimmune diseases by acting on the innate and acquired immune system to inhibit the function of Th1 and Th17 cells. Th1 and Th17 cells are important in host resistance to many infections including tuberculosis (TB) caused by Mycobacterium tuberculosis. Paradoxically the innate immune system is induced to produce antibacterial peptides that are effective against TB in vitro. Data from several models of infection have so far not supported a role for vitamin D in affecting the course of disease. There is also very little evidence that vitamin D affects the course of human TB infection. Experiments have not been done in cells, mice or humans to evaluate the effect of vitamin D on influenza virus. At this time it would be premature to claim that vitamin D has an effect on TB, influenza or any other infection.

AB - Vitamin D is being touted as an anti-infective agent and it has even been suggested that vitamin D supplementation could be effective against the H1N1 influenza virus. The claims are largely based on the ability of vitamin D to induce antibacterial peptides and evidence that the immune system produces active vitamin D (1,25(OH)2D3) in situ. While there are many examples of immune production of 1,25(OH)2D3 in vitro, there is little in vivo evidence. In addition, it is not clear what role immune production of 1,25(OH)2D3 has on the course of disease. Vitamin D and 1,25(OH)2D3 inhibit T helper type 1 (Th1)/ Th17-mediated immune responses and autoimmune diseases by acting on the innate and acquired immune system to inhibit the function of Th1 and Th17 cells. Th1 and Th17 cells are important in host resistance to many infections including tuberculosis (TB) caused by Mycobacterium tuberculosis. Paradoxically the innate immune system is induced to produce antibacterial peptides that are effective against TB in vitro. Data from several models of infection have so far not supported a role for vitamin D in affecting the course of disease. There is also very little evidence that vitamin D affects the course of human TB infection. Experiments have not been done in cells, mice or humans to evaluate the effect of vitamin D on influenza virus. At this time it would be premature to claim that vitamin D has an effect on TB, influenza or any other infection.

UR - http://www.scopus.com/inward/record.url?scp=77955679839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955679839&partnerID=8YFLogxK

U2 - 10.1258/ebm.2010.010061

DO - 10.1258/ebm.2010.010061

M3 - Short survey

C2 - 20660091

AN - SCOPUS:77955679839

VL - 235

SP - 921

EP - 927

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 1535-3702

IS - 8

ER -