Vitamin D deficiency, hypocalcemia, and increased skeletal muscle degradation in rats

S. J. Wassner, J. B. Li, A. Sperduto, M. E. Norman

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies and demonstrated that myofibrillar protein degradation was increased in vitamin D deficiency. Normal growth rates could be maintained by feeding the rats vitamin D-deficient diets containing 1.6% calcium, which maintained plasma calcium within the normal range. In addition to its role in maintaining plasma calcium, vitamin D-supplemented rats had significantly higher levels of the anabolic hormone insulin. Vitamin D supplementation may affect muscle protein turnover by preventing hypocalcemia, as well as well as directly stimulating insulin secretion, rather than by a direct effect within skeletal muscle.

Original languageEnglish (US)
Pages (from-to)102-112
Number of pages11
JournalJournal of Clinical Investigation
Volume72
Issue number1
DOIs
StatePublished - Jan 1 1983

Fingerprint

Vitamin D Deficiency
Hypocalcemia
Vitamin D
Skeletal Muscle
Muscle Proteins
Calcium
Muscles
Insulin
Phosphocreatine
Muscular Diseases
Proteolysis
Weight Gain
Reference Values
Hormones
Diet
Growth

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Wassner, S. J. ; Li, J. B. ; Sperduto, A. ; Norman, M. E. / Vitamin D deficiency, hypocalcemia, and increased skeletal muscle degradation in rats. In: Journal of Clinical Investigation. 1983 ; Vol. 72, No. 1. pp. 102-112.
@article{81ea06f36c23476d8061c2747d4af352,
title = "Vitamin D deficiency, hypocalcemia, and increased skeletal muscle degradation in rats",
abstract = "The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies and demonstrated that myofibrillar protein degradation was increased in vitamin D deficiency. Normal growth rates could be maintained by feeding the rats vitamin D-deficient diets containing 1.6{\%} calcium, which maintained plasma calcium within the normal range. In addition to its role in maintaining plasma calcium, vitamin D-supplemented rats had significantly higher levels of the anabolic hormone insulin. Vitamin D supplementation may affect muscle protein turnover by preventing hypocalcemia, as well as well as directly stimulating insulin secretion, rather than by a direct effect within skeletal muscle.",
author = "Wassner, {S. J.} and Li, {J. B.} and A. Sperduto and Norman, {M. E.}",
year = "1983",
month = "1",
day = "1",
doi = "10.1172/JCI110947",
language = "English (US)",
volume = "72",
pages = "102--112",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "1",

}

Vitamin D deficiency, hypocalcemia, and increased skeletal muscle degradation in rats. / Wassner, S. J.; Li, J. B.; Sperduto, A.; Norman, M. E.

In: Journal of Clinical Investigation, Vol. 72, No. 1, 01.01.1983, p. 102-112.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin D deficiency, hypocalcemia, and increased skeletal muscle degradation in rats

AU - Wassner, S. J.

AU - Li, J. B.

AU - Sperduto, A.

AU - Norman, M. E.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies and demonstrated that myofibrillar protein degradation was increased in vitamin D deficiency. Normal growth rates could be maintained by feeding the rats vitamin D-deficient diets containing 1.6% calcium, which maintained plasma calcium within the normal range. In addition to its role in maintaining plasma calcium, vitamin D-supplemented rats had significantly higher levels of the anabolic hormone insulin. Vitamin D supplementation may affect muscle protein turnover by preventing hypocalcemia, as well as well as directly stimulating insulin secretion, rather than by a direct effect within skeletal muscle.

AB - The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies and demonstrated that myofibrillar protein degradation was increased in vitamin D deficiency. Normal growth rates could be maintained by feeding the rats vitamin D-deficient diets containing 1.6% calcium, which maintained plasma calcium within the normal range. In addition to its role in maintaining plasma calcium, vitamin D-supplemented rats had significantly higher levels of the anabolic hormone insulin. Vitamin D supplementation may affect muscle protein turnover by preventing hypocalcemia, as well as well as directly stimulating insulin secretion, rather than by a direct effect within skeletal muscle.

UR - http://www.scopus.com/inward/record.url?scp=0020576642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020576642&partnerID=8YFLogxK

U2 - 10.1172/JCI110947

DO - 10.1172/JCI110947

M3 - Article

C2 - 6308041

AN - SCOPUS:0020576642

VL - 72

SP - 102

EP - 112

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 1

ER -