Vitamin D metabolites across the menstrual cycle

A systematic review

Anita Subramanian, Alison Diane Gernand

Research output: Contribution to journalReview article

Abstract

Background: Accurate estimation of vitamin D status is important for health research and can impact prevention and treatment of deficiency in women of reproductive age. We aimed to assess if blood concentrations of 25-hydroxyvitamin D [25(OH)D] or 1,25-dihydroxyvitamin D [1,25(OH) 2 D] change across the menstrual cycle. Methods: We conducted a systematic search in PubMed, Web of Science, CAB and BIOSIS of literature published until December 2018 which reported concentrations of vitamin D metabolites at two or more identified points among women with regular menstrual cycles. Results: Ten longitudinal studies met the inclusion criteria; nine studies measured 1,25(OH) 2 D and five studies measured 25(OH)D. Study size ranged from 5 to 47 subjects, with an age range of 18-47 years. One study found a decrease in concentration of 25(OH)D in the periovulatory and luteal phase. Four studies found no changes in concentrations of 25(OH)D. Two studies found a rise in 1,25(OH) 2 D within the follicular phase, including a 128% increase from day 1 to 15 and a 56% increase from day 0 to 12. Two studies found rises in 1,25(OH) 2 D concentrations from the follicular to luteal phase of 13 and 26%. Five studies did not find any changes in concentrations of 1,25(OH) 2 D. Conclusions: No conclusion can be drawn on the pattern of 1,25(OH) 2 D concentrations across the normal menstrual cycle due to inconsistencies in study findings. Evidence is currently insufficient to assess 25(OH)D concentrations across the cycle. Future studies should aim to measure 1,25(OH) 2 D and 25(OH)D longitudinally, to understand relationships with other hormones and the potential impact on estimates of vitamin D deficiency.

Original languageEnglish (US)
Article number19
JournalBMC Women's Health
Volume19
Issue number1
DOIs
StatePublished - Jan 28 2019

Fingerprint

Menstrual Cycle
Vitamin D
Luteal Phase
Vitamin D Deficiency
Follicular Phase
PubMed
Longitudinal Studies
Hormones
Health
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

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title = "Vitamin D metabolites across the menstrual cycle: A systematic review",
abstract = "Background: Accurate estimation of vitamin D status is important for health research and can impact prevention and treatment of deficiency in women of reproductive age. We aimed to assess if blood concentrations of 25-hydroxyvitamin D [25(OH)D] or 1,25-dihydroxyvitamin D [1,25(OH) 2 D] change across the menstrual cycle. Methods: We conducted a systematic search in PubMed, Web of Science, CAB and BIOSIS of literature published until December 2018 which reported concentrations of vitamin D metabolites at two or more identified points among women with regular menstrual cycles. Results: Ten longitudinal studies met the inclusion criteria; nine studies measured 1,25(OH) 2 D and five studies measured 25(OH)D. Study size ranged from 5 to 47 subjects, with an age range of 18-47 years. One study found a decrease in concentration of 25(OH)D in the periovulatory and luteal phase. Four studies found no changes in concentrations of 25(OH)D. Two studies found a rise in 1,25(OH) 2 D within the follicular phase, including a 128{\%} increase from day 1 to 15 and a 56{\%} increase from day 0 to 12. Two studies found rises in 1,25(OH) 2 D concentrations from the follicular to luteal phase of 13 and 26{\%}. Five studies did not find any changes in concentrations of 1,25(OH) 2 D. Conclusions: No conclusion can be drawn on the pattern of 1,25(OH) 2 D concentrations across the normal menstrual cycle due to inconsistencies in study findings. Evidence is currently insufficient to assess 25(OH)D concentrations across the cycle. Future studies should aim to measure 1,25(OH) 2 D and 25(OH)D longitudinally, to understand relationships with other hormones and the potential impact on estimates of vitamin D deficiency.",
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Vitamin D metabolites across the menstrual cycle : A systematic review. / Subramanian, Anita; Gernand, Alison Diane.

In: BMC Women's Health, Vol. 19, No. 1, 19, 28.01.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Vitamin D metabolites across the menstrual cycle

T2 - A systematic review

AU - Subramanian, Anita

AU - Gernand, Alison Diane

PY - 2019/1/28

Y1 - 2019/1/28

N2 - Background: Accurate estimation of vitamin D status is important for health research and can impact prevention and treatment of deficiency in women of reproductive age. We aimed to assess if blood concentrations of 25-hydroxyvitamin D [25(OH)D] or 1,25-dihydroxyvitamin D [1,25(OH) 2 D] change across the menstrual cycle. Methods: We conducted a systematic search in PubMed, Web of Science, CAB and BIOSIS of literature published until December 2018 which reported concentrations of vitamin D metabolites at two or more identified points among women with regular menstrual cycles. Results: Ten longitudinal studies met the inclusion criteria; nine studies measured 1,25(OH) 2 D and five studies measured 25(OH)D. Study size ranged from 5 to 47 subjects, with an age range of 18-47 years. One study found a decrease in concentration of 25(OH)D in the periovulatory and luteal phase. Four studies found no changes in concentrations of 25(OH)D. Two studies found a rise in 1,25(OH) 2 D within the follicular phase, including a 128% increase from day 1 to 15 and a 56% increase from day 0 to 12. Two studies found rises in 1,25(OH) 2 D concentrations from the follicular to luteal phase of 13 and 26%. Five studies did not find any changes in concentrations of 1,25(OH) 2 D. Conclusions: No conclusion can be drawn on the pattern of 1,25(OH) 2 D concentrations across the normal menstrual cycle due to inconsistencies in study findings. Evidence is currently insufficient to assess 25(OH)D concentrations across the cycle. Future studies should aim to measure 1,25(OH) 2 D and 25(OH)D longitudinally, to understand relationships with other hormones and the potential impact on estimates of vitamin D deficiency.

AB - Background: Accurate estimation of vitamin D status is important for health research and can impact prevention and treatment of deficiency in women of reproductive age. We aimed to assess if blood concentrations of 25-hydroxyvitamin D [25(OH)D] or 1,25-dihydroxyvitamin D [1,25(OH) 2 D] change across the menstrual cycle. Methods: We conducted a systematic search in PubMed, Web of Science, CAB and BIOSIS of literature published until December 2018 which reported concentrations of vitamin D metabolites at two or more identified points among women with regular menstrual cycles. Results: Ten longitudinal studies met the inclusion criteria; nine studies measured 1,25(OH) 2 D and five studies measured 25(OH)D. Study size ranged from 5 to 47 subjects, with an age range of 18-47 years. One study found a decrease in concentration of 25(OH)D in the periovulatory and luteal phase. Four studies found no changes in concentrations of 25(OH)D. Two studies found a rise in 1,25(OH) 2 D within the follicular phase, including a 128% increase from day 1 to 15 and a 56% increase from day 0 to 12. Two studies found rises in 1,25(OH) 2 D concentrations from the follicular to luteal phase of 13 and 26%. Five studies did not find any changes in concentrations of 1,25(OH) 2 D. Conclusions: No conclusion can be drawn on the pattern of 1,25(OH) 2 D concentrations across the normal menstrual cycle due to inconsistencies in study findings. Evidence is currently insufficient to assess 25(OH)D concentrations across the cycle. Future studies should aim to measure 1,25(OH) 2 D and 25(OH)D longitudinally, to understand relationships with other hormones and the potential impact on estimates of vitamin D deficiency.

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U2 - 10.1186/s12905-019-0721-6

DO - 10.1186/s12905-019-0721-6

M3 - Review article

VL - 19

JO - BMC Women's Health

JF - BMC Women's Health

SN - 1472-6874

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M1 - 19

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